32444-63-6Relevant articles and documents
NOVEL SMALL MOLECULES THAT BIND AND/OR MODULATE DIFFERENTFORMS OF TAU OLIGOMERS
-
Page/Page column 34; 35, (2020/11/03)
The present invention relates to novel small molecules of Formulas I, II, III, Ilia, Illb, and IV and pharmaceutically acceptable salts thereof, as well as the preparation and the use thereof.
Catalytic sp3C-CN Bond Cleavage: Ni-Mediated Phosphorylation of Alkylnitriles
Zhang, Ji-Shu,Chen, Tieqiao,Zhou, Yongbo,Yin, Shuang-Feng,Han, Li-Biao
supporting information, p. 6746 - 6749 (2018/10/25)
A direct phosphorylation of the sp3C-CN bond catalyzed by a nickel catalyst is disclosed. A wide range of primary nitriles readily coupled with secondary phosphine oxides to produce the corresponding phosphorylated products in high yields. As a key step, this new method was applied to the synthesis of anticancer drug Combretastatin-A4, significantly shortening its synthetic path.
Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors
Hamada, Shohei,Kim, Tae-Dong,Suzuki, Takayoshi,Itoh, Yukihiro,Tsumoto, Hiroki,Nakagawa, Hidehiko,Janknecht, Ralf,Miyata, Naoki
scheme or table, p. 2852 - 2855 (2010/07/03)
N-Oxalylglycine (NOG) derivatives were synthesized, and their inhibitory effect on histone lysine demethylase activity was evaluated. NOG and compound 1 inhibited histone lysine demethylases JMJD2A, 2C and 2D in enzyme assays, and their dimethyl ester prodrugs DMOG and 21 exerted histone lysine methylating activity in cellular assays.
Synthesis of 2,6-dimethyl-4-substituted pyridine-3,5-dicarbonitriles from β-aminoacrylonitriles
Al-Omran,El-Khair
, p. 608 - 611 (2007/10/03)
β-Aminoacrylonitrile reacts with aldehydes or cinnamaldehyde in the presence of HCl to give 2,6-dimethyl-4-substituted pyridine-3,5-dicarbo/nitrites 2a-c. 2a-b on condensation with DMF/DMA afford 8a-b. Reaction of 2b with 4-N,N-dimethylaminobenzaldehyde yields 8c. The structures of the newly synthesized compounds have been elucidated by elemental analyses and spectral data.
Direct Synthesis of α,β-Unsaturated Nitriles Catalyzed by Nonionic Superbases
D'Sa, Bosco A.,Kisanga, Philip,Verkade, John G.
, p. 3961 - 3967 (2007/10/03)
We report herein the use of 3-30 mol % of a new class of tricyclic strong nonionic Lewis bases P(MeNCH2CH2)3N and P(HNCH2CH2)(i-PrNCH2CH2) 2N for the direct catalytic synthesis of a variety of functionalized α,β-unsaturated nitriles in high yields from aldehydes and acetonitrile or benzyl cyanide at 40-50°C. Evidence for a novel mechanistic pathway proposed for this reaction in a polar protic solvent such as methanol, and a nonpolar aprotic solvent such as benzene is also presented. Under these conditions, primary and secondary aliphatic aldehydes do not condense satisfactorily with acetonitrile to give the α,β-unsaturated nitrile, and ketones do not condense with either benzyl cyanide or acetonitrile.
Electrogenerated superoxide in the synthesis of α,β-unsaturated nitriles
Dwivedi, Suchitra,Misra, Ram Achal
, p. 694 - 695 (2007/10/02)
Various aromatic aldehydes (1a-7a) when allowed to react in acetonitrile medium with electrogenerated superoxide ion smoothly afford the corresponding α,β-unsaturated nitriles (1b-7b).This procedure constitutes an alternative access to the title compounds.
