324748-62-1

Basic information

• Product Name: 1-Benzyl-3(R)isopropylpiperazine
• Synonyms: (S)-N4-BENZYL-2-ISOPROPYLPIPERAZINE;(S)-4-Benzyl-2-isopropylpiperazine;N4-BENZYL-2-ISOPROPYLPIPERAZINE;1-Benzyl-3(R)isopropylpiperazine;(S)-1-Benzyl-3-isopropylpiperazine;(R)-1-benzyl-3-isopropylpiperazine;(S)-1-Benzyl-3-isopropylpiperazine, 98+%;(3S)-3-(1-methylethyl)-1-(phenylmethyl)-Piperazine
• CAS NO: 324748-62-1
• Molecular Formula: C₁₄H₂₂N₂
• Molecular Weight: 218.34
• Product Categories: pharmacetical
• Mol File: 324748-62-1.mol

Chemical Properties

• Boiling Point: 309.596ºC at 760 mmHg
• Flash Point: 112.796ºC
• Appearance: /
• Density: 0.975g/cm3
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 1-Benzyl-3(R)isopropylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-3(R)isopropylpiperazine(324748-62-1)
• EPA Substance Registry System: 1-Benzyl-3(R)isopropylpiperazine(324748-62-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 324748-62-1(Hazardous Substances Data)

Usage

Uses

1-Benzyl-3(R)isopropylpiperazine is used as a psychoactive substance for its stimulating and euphoric effects. However, it is important to note that it is not approved for medical use and has been identified as a potential drug of abuse. The recreational use of this chemical is discouraged due to the potential dangers associated with its consumption, including risks to human health and altered states of consciousness.

InChI:InChI=1/C14H22N2/c1-12(2)14-11-16(9-8-15-14)10-13-6-4-3-5-7-13/h3-7,12,14-15H,8-11H2,1-2H3

Upstream product

• 1492-06-4 methyl (S)-2-(2-chloroacetylamino)-2,3-dimethylbutanoate 
• 4070-48-8 L-Valine methyl ester 
• 220663-44-5 (S)-1-benzyl-3-isopropylpiperazine-2,5-dione 
• 100-46-9 benzylamine 
• 13734-41-3 t-Boc-L-valine 

Downstream Products

• 674791-99-2 (S)-tert-butyl 2-isopropyl-4-benzylpiperazine-1-carboxylate 
• 1007112-70-0 (S)-methyl 2-(4-benzyl-2-isopropylpiperazin-1-yl)benzoxazole-4-carboxylate 
• 84468-53-1 (S)-2-isopropylpiperazine 

Relevant articles and documents

Structure-Activity Relationship Studies on Oxazolo[3,4- a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent in Vivo Activity

Neuropeptide S modulates important neurobiological functions including locomotion, anxiety, and drug abuse through interaction with its G protein-coupled receptor known as neuropeptide S receptor (NPSR). NPSR antagonists are potentially useful for the treatment of substance abuse disorders against which there is an urgent need for new effective therapeutic approaches. Potent NPSR antagonists in vitro have been discovered which, however, require further optimization of their in vivo pharmacological profile. This work describes a new series of NPSR antagonists of the oxazolo[3,4-a]pyrazine class. The guanidine derivative 16 exhibited nanomolar activity in vitro and 5-fold improved potency in vivo compared to SHA-68, a reference pharmacological tool in this field. Compound 16 can be considered a new tool for research studies on the translational potential of the NPSergic system. An in-depth molecular modeling investigation was also performed to gain new insights into the observed structure-activity relationships and provide an updated model of ligand/NPSR interactions.

Efficient one-pot synthesis of enantiomerically pure: N -protected-α-substituted piperazines from readily available α-amino acids

A new pathway towards enantiomerically pure 3-substituted piperazines, bearing a benzyl protecting group, has been developed in good overall yields (83-92%), starting from commercially available N-protected amino acids. The methodology represents an efficient and simple one-pot procedure, employing a synthetic sequence consisting of an Ugi-4 component reaction, a Boc-deprotection, an intramolecular cyclisation reaction and a final reduction (UDCR). From the benzyl protected precursors, the 2-substituted piperazines bearing a Boc-protecting group could consequently also be obtained via a simple protection and deprotection step of the corresponding piperazines. The practical utility of this methodology was demonstrated for chiral drug synthesis.

PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES

The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.Formula (I)

PIPERAZINE UREA DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS

Certain novel piperazine urea derivatives are agonists of the human melanocortin-4 receptor (MC-4R) and, in particular, are receptor-subtype selective agonists of MC-4R. They are useful for the treatment, control, or prevention of diseases and disorders r

Piperazine derivative

A piperazine compound represented by formula (1): wherein X is —CH2—, —C(O)— or —CH(CH3)—; R1is a hydrogen atom or alkyl group; and R2is a hydrogen atom, alkyl group, hydroxyalkyl group, arylalkyl group, heteroarylalkyl group, carboxyalkyl group, carboxamidoalkyl group, aminoalkyl group or guanidinoalkyl group; an acid-addition salt thereof, or a hydrate thereof. The compound has excellent inhibitory effects on both cell adhesion and cell infiltration and is useful for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation.

BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS

The present invention provides serotonergic benzofurylpiperazines of Formula I: where: A is a piperazine of formula: and R, R1, R2, R3, R4, R5, R5', R6, R6', R7, R7', R8, and R8' are as described in the specification.