4070-48-8

Usage

Uses

Used in Pharmaceutical Industry:
L-Valine methyl ester is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and enhance their efficacy.
Used in Medical Research:
L-Valine methyl ester serves as a building block in the synthesis of novel compounds for medical research, aiding in the discovery of potential therapeutic agents.
Used in Food Industry:
L-Valine methyl ester is used as a flavoring agent in the food industry, enhancing the taste and aroma of various food products.
Used in Fragrance Industry:
L-Valine methyl ester is utilized as a fragrance enhancer in the fragrance industry, improving the scent profiles of various products.
Used in Biological Applications:
L-Valine methyl ester is employed in biological applications for its potential role in various biological processes and its ability to contribute to a better understanding of cellular mechanisms.
Used in Medical Applications:
L-Valine methyl ester has demonstrated potential in medical applications, such as the development of targeted drug delivery systems and the enhancement of therapeutic outcomes in various medical conditions.

Upstream product

• 67-56-1 methanol 
• 640-68-6 D-Val-OH 
• 142573-48-6 1,3-Bis<(2'R,5'S)-2',5'-dihydro-3',6'-dimethoxy-2'-isopropylpyrazin-5'-yl>propan 
• 144665-50-9 (3R,6S,2''S)-(+)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-6-<(methylenecyclopropyl)methyl>pyrazin 
• 144604-87-5 (3R,6S,2''R)-(+)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-6-<(methylenecyclopropyl)methyl>pyrazin 
• 5619-05-6 DL-valine methyl ester hydrochloride 
• 432550-82-8 N-benzoyl-N-ethanoylamino-2-[(S)-1-tert-butyldimethylsilyloxy-2-methylpropyl]quinazolin-4(3H)-one 
• 952524-02-6 (S)-1-benzoyl-2-(α-acetoxyethyl)benzimidazole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 113489-54-6 (3R,6S)-6-Isopropyl-5,8-dimethoxy-1-phenyl-4,7-diaza-spiro[2.5]octa-1,4,7-triene 
• 113489-55-7 (3R,6S)-6-Isopropyl-5,8-dimethoxy-1-p-tolyl-4,7-diaza-spiro[2.5]octa-1,4,7-triene 
• 113489-56-8 (3R,6S)-1-(4-Chloro-phenyl)-6-isopropyl-5,8-dimethoxy-4,7-diaza-spiro[2.5]octa-1,4,7-triene 
• 84907-82-4 (3R,6S)-3,6-Dihydro-3-(1-hydroxy-1-methylethyl)-6-isopropyl-2,5-dimethoxypyrazin 
• 81136-87-0 (2S,5R)-2,5-dihydro-2-isopropyl-3,6-dimethoxy-5-benzyl-5-methylpyrazine 

Downstream Products

• 110253-12-8 optically inactive N-[1-methoxycarbonyl-1-(2-phenyl-acetylamino)-ethyl]-valine methyl ester 
• 114252-89-0 N-[(SR)-2-methoxycarbonyl-2-(2-phenyl-acetylamino)-ethyl]-DL-valine methyl ester 
• 114252-89-0 N-[(RS)-2-methoxycarbonyl-2-(2-phenyl-acetylamino)-ethyl]-DL-valine methyl ester 
• 121426-48-0 N-benzyloxycarbonyl-glycyl=>leucyl=>-valine methyl ester 
• 36207-48-4 DL-valine hydroxamic acid 
• 40216-62-4 methyl 2-(benzylamino)-3-methylbutanoate 
• 38648-74-7 N-Thiobenzoyl-DL-valinmethylester 
• 16369-05-4 valinol 
• 17645-51-1 valine benzyl ester 
• 133175-32-3 (R)-2-((R)-2-Fluoro-2-phenyl-acetylamino)-3-methyl-butyric acid methyl ester 
• 133175-48-1 (S)-2-((R)-2-Fluoro-2-phenyl-acetylamino)-3-methyl-butyric acid methyl ester 
• 77119-22-3 2-[(1-Benzyl-aziridine-2-carbonyl)-amino]-3-methyl-butyric acid methyl ester 
• 134306-34-6 N-(Benzyloxycarbonyl)valine methyl ester 
• 626-48-2 6-Methyluracil 

Relevant academic research and scientific papers

N-Pyrazinoyl substituted amino acids as potential antimycobacterial agents-the synthesis and biological evaluation of enantiomers

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb), each year causing millions of deaths. In this article, we present the synthesis and biological evaluations of new potential antimycobacterial compounds containing a fragment of the first-line antitubercular drug pyrazinamide (PZA), coupled with methyl or ethyl esters of selected amino acids. The antimicrobial activity was evaluated on a variety of (myco)bacterial strains, including Mtb H37Ra, M. smegmatis, M. aurum, Staphylococcus aureus, Pseudomonas aeruginosa, and fungal strains, including Candida albicans and Aspergillus flavus. Emphasis was placed on the comparison of enantiomer activities. None of the synthesized compounds showed any significant activity against fungal strains, and their antibacterial activities were also low, the best minimum inhibitory concentration (MIC) value was 31.25 μM. However, several compounds presented high activity against Mtb. Overall, higher activity was seen in derivatives containing l-amino acids. Similarly, the activity seems tied to the more lipophilic compounds. The most active derivative contained phenylglycine moiety (PC-d/l-Pgl-Me, MIC 1.95 μg/mL). All active compounds possessed low cytotoxicity and good selectivity towards Mtb. To the best of our knowledge, this is the first study comparing the activities of the d- and l-amino acid derivatives of pyrazinamide as potential antimycobacterial compounds.

Exciton-Coupled Circular Dichroism Characterization of Monotopically Binding Guests in Host?Guest Complexes with a Bis(zinc porphyrin) Tweezer

A stiff-stilbene-linked bisporphyrin tweezer with inherent helicity was used for exciton-coupled circular dichroism (ECCD) characterization of a series of monotopically binding amine guest molecules. CD signals were observed for a variety of monoamines at relatively low tweezer/amine (host/guest) ratios between 1 : 10 to 1 : 70. For the amines producing the most intense CD signals, a binding stoichiometry of 1 : 2 was found. A likely explanation is the presence of guest-guest interactions in the complexes. This is supported by the correlation observed between CD signal intensity and magnitude of possible noncovalent binding between the guests, which can be divided into three groups showing no, moderate and strong response, respectively. Further support for this rationalization comes from molecular modelling.

Method for preparing amino ether compounds

The invention belongs to the technical field of organic synthesis and relates to a method for preparing amino ether compounds. The method comprises the following steps: by taking amino alcohol as a raw material, protecting amino in the amino alcohol so as to obtain Schiff base; carrying out an etherification reaction on the hydroxyl group in the Schiff base; and finally, performing amino deprotection, thereby obtaining corresponding amino ethers. The method disclosed by the invention has high regio-selectivity, the substrates of higher than 99.9% are subjected to etherification reaction, the reaction conversion ratio of each step is higher than 99.8%, and the total yield is higher than 95%; when amino alcohol is chiral, the amino ethers with retention of configuration can be obtained; and moreover, each step of the method is a conventional operation, the process cost is low, and three wastes are few, the energy consumption is low, an environment-friendly effect is achieved, and large-scale industrial production is easily realized.

STABILIZED POLYPEPTIDES AND USES THEREOF

The present invention provides inventive stabilized STAT polypeptides, pharmaceutical compositions thereof, and methods of making and using inventive stabilized STAT polypeptides.

In situ deprotection and incorporation of unnatural amino acids during cell-free protein synthesis

The S30 extract from E. coli BL21 Star (DE3) used for cell-free protein synthesis removes a wide range of α-amino acid protecting groups by cleaving α-carboxyl hydrazides; methyl, benzyl, tert-butyl, and adamantyl esters; tert-butyl and adamantyl carboxamides; α-amino form-, acet-, trifluoroacet-, and benzamides and sidechain hydrazides and esters. The free amino acids are produced and incorporated into a protein under standard conditions. This approach allows the deprotection of amino acids to be carried out in situ to avoid separate processing steps. The advantages of this approach are demonstrated by the efficient incorporation of the chemically intractable (S)-4-fluoroleucine, (S)-4,5- dehydroleucine, and (2S,3R)-4-chlorovaline into a protein through the direct use of their respective precursors, namely, (S)-4-fluoroleucine hydrazide, (S)-4,5-dehydroleucine hydrazide, and (2S,3R)-4-chlorovaline methyl ester. These results also show that the fluoroand dehydroleucine and the chlorovaline are incorporated into a protein by the normal biosynthetic machinery as substitutes for leucine and isoleucine, respectively. Copyright

Asperelines A-F, peptaibols from the marine-derived fungus Trichoderma asperellum

Fermentation of the marine-derived fungus Trichoderma asperellum, collected from the sediment of the Antarctic Penguin Island, resulted in the isolation of six new peptaibols named asperelines A-F (1-6), which are characterized by an acetylated N-terminus and a C-terminus containing an uncommon prolinol residue. Structures were determined by extensive 1D and 2D NMR (1H- 1H COSY, HMQC, HMBC, NOESY) spectroscopic data analysis combined with ESIMS/MS fragmentation. The absolute configurations of the amino acid residues possessing a chiral R-carbon and of the prolinol residue were determined to be L and S, respectively, using a new method of 1H NMR spectroscopic comparison of complexes formed between the chiral reagent Ru(D 4-Por*)CO and amino acids derived from the peptaibols with those formed with reference standards.

A novel naphthylmethyleneimino-type photocleavable protecting group for primary amines

A novel naphthylmethyleneimino-type protecting group for aliphatic and aromatic primary amines including α-amino acids was devised and its introduction was accomplished in good to excellent yields. This type of protecting group was found to be cleanly removed photochemically to regenerate the primary amines in good to high yields, regardless of steric and electronic properties. Georg Thieme Verlag Stuttgart.

Enantioselective benzoylation of α-amino esters using (S)-1-benzoyl-2-(α-acetoxyethyl)benzimidazole, a chiral benzimidazolide

(Chemical Equation Presented) A new chiral benzimidazolide is developed as a nonenzymatic acylating agent for enantioselective benzoylation of racemic α-amino esters. The process is highly efficient, which exhibits uniformly high enantioselectivity for α-amino esters with or without aryl substituents under mild reaction conditions. The chiral benzimidazolide is inexpensive and is easily accessible.

Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates

Sequential enolate alkylations of (S)-N(1)-methyl-5-methoxy-6-isopropyl-3, 6-dihydropyrazin-2-one and (S)-N(1)-p-methoxybenzyl-5-methoxy-6-isopropyl-3,6- dihydropyrazin-2-one proceed with excellent levels of diastereoselectivity (>90% de) affording quaternary α-amino acids in high enantiomeric excess (>98% ee) after deprotection and hydrolysis. This journal is The Royal Society of Chemistry.