324767-96-6Relevant articles and documents
ETHYL 6-[(2-CHLORO-4-FLUOROPHENYL)METHANESULFONYL]-3-METHYLCYCLOHEX-1-ENE-1-CARBOXYLATE AS TLR4 ANTAGONIST
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Paragraph 0075; 0076, (2018/02/28)
The invention provides a compound of ethyl 6- [ (2-chloro- 4-fluorophenyl)methanesulfonyl] -3-methylcyclohex-1-ene-1- carboxylate. The compound possesses an advantageous combination of TLR4 antagonist properties and brain permeability, and therefore, the compound would be expected to be useful in the treatment of central nervous system diseases mediated at least in part by TLR4.