326594-27-8 Usage
Uses
Used in Pharmaceutical Industry:
1-Trityl-3-Methylpiperazine is used as a synthetic intermediate for the preparation of methylnitroquipazines, which are serotonin transporter inhibitors. These inhibitors play a crucial role in the development of medications targeting various central nervous system disorders, such as depression and anxiety, by modulating the levels of serotonin in the brain.
Check Digit Verification of cas no
The CAS Registry Mumber 326594-27-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,6,5,9 and 4 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 326594-27:
(8*3)+(7*2)+(6*6)+(5*5)+(4*9)+(3*4)+(2*2)+(1*7)=158
158 % 10 = 8
So 326594-27-8 is a valid CAS Registry Number.
326594-27-8Relevant articles and documents
Serotonin transporter inhibitors: Synthesis and binding potency of 2'-methyl- and 3'-methyl-6-nitroquipazine
Gerdes, John M.,DeFina, Steven C.,Wilson, Paul A.,Taylor, Scott E.
, p. 2643 - 2646 (2000)
Racemic 2'-methyl- and 3'-methyl-6-nitroquipazine ligands were selected as targets, synthesized and evaluated at the serotonin transporter employing an in vitro competitive inhibition assay with [3H]paroxetine and rat cortical membrane. The 2'-methyl-6-nitroquipazine was found to be 50 times more potent than the 3'-methyl-substituted counterpart and of comparable potency to the known high affinity agent 5-iodo-6-nitroquipazine. (C) 2000 Elsevier Science Ltd.
