32803-73-9

Basic information

• Product Name: Benzenepropanoic acid, b-chloro-a-oxo-, methyl ester
• Synonyms: 3-Phenyl-3-chloro-2-oxopropionic acid methyl ester;methyl phenylchloropyruvate;methyl 3-chloro-2-oxo-3-phenylpropanoate;3-phenyl-3-chloro-2-ketopropionic acid methyl ester;methyl 3-phenyl-3-chloro-2-ketopropionate;2-oxo-3-phenyl-3-chloropropionic acid methyl ester
• CAS NO: 32803-73-9
• Molecular Formula: C10H9ClO3
• Molecular Weight: 212.633
• Mol File: 32803-73-9.mol

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, b-chloro-a-oxo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, b-chloro-a-oxo-, methyl ester(32803-73-9)
• EPA Substance Registry System: Benzenepropanoic acid, b-chloro-a-oxo-, methyl ester(32803-73-9)

Safety Data

• Hazardous Substances Data: 32803-73-9(Hazardous Substances Data)

Upstream product

• 90179-18-3 (erythro-threo)-methyl-2-cyano-3-fluoro-2-hydroxy-3-phenylpropanoate 
• 116-54-1 dichloroacetic acid methyl ester 
• 100-52-7 benzaldehyde 
• 29653-30-3 dimethyl 2,2-dichloromalonate 

Downstream Products

• 132525-00-9 2-methoxycarbonyl-3-phenylimidazo<1,2-a>pyridine 
• 115174-40-8 2-Allylamino-5-phenyl-thiazole-4-carboxylic acid methyl ester; hydrochloride 
• 132525-01-0 2-methoxycarbonyl-3-phenyl-6-bromoimidazo<1,2-a>pyridine 
• 132524-98-2 2-methoxycarbonyl-3-hydro-3-phenyl-6-bromoimidazo<1,2-a>pyridinium-4 chloride 
• 132524-99-3 2-methoxycarbonyl-3-phenylimidazo<1,2-a>quinoline 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 115174-41-9 5-Phenyl-thiazole-4-carboxylic acid methyl ester; hydrochloride 
• 136744-10-0 methyl -3-phenyl-2-oxopropionate hydrochloride 
• 119751-51-8 3-phenyl-3-methoxy-2-ketopropionic acid methyl ester 
• 132545-33-6 3-methoxy-2,5-dimethoxycarbonyl-3,6-diphenyl-2,3-dihydro-1,4-dioxin 
• 123432-08-6 3-phenyl-3-ethoxy-2-ketopropionic acid ethyl ester 
• 123432-07-5 2,5-diketo-3,4-diphenyl-3-ethoxyhexanedioic acid diethyl ester 
• 139156-75-5 methyl 2-<2'-(2''-methyl-5''-phenylthiazolecarbonyl)hydrazo>-5-phenylthiazolecarboxylate 
• 4519-51-1 α-chlorocinnamic acid methyl ester 

Relevant articles and documents

Intermolecular cyclocondensation of arylchloropyruvates in the synthesis of 2,3-dihydrofuran-3,5-dicarboxylic acid derivatives

Methyl arylchloropyruvates undergo intermolecular self-condensation in the presence of a catalytic amount of a base under high-temperature conditions (~250°C) with the formation of 3,4-diaryl-2-oxo-2,3-dihydrofuran-3,5-dicarboxylic acid derivatives.

SUBSTITUTED 2-AZABICYCLO[3.1.1]HEPTANE AND 2-AZABICYCLO[3.2.1]OCTANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

There is provided a compound of formula (I), wherein L1 to L3, R1 to R4, X, A and B have meanings given in the description, and pharmaceutically acceptable salts, solvates and prodrugs thereof, which compounds are useful as antagonists of the orexin-1 and orexin-2 receptors or as selective antagonists of the orexin-1 receptor, and thus, in particular, in the treatment or prevention of inter alia substance dependence, addiction, anxiety disorders, panic disorders, binge eating, compulsive disorders, impulse control disorders, cognitive impairment and Alzheimer's disease.

OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS

The invention relates to oxazole and thiazole derivatives of formula (I), wherein A, E, X, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

2-AZA-BICYCLO[3.3.0]OCTANE DERIVATIVES

The invention relates to 2-aza-bicyclo[3.3.0]octane derivatives of Formula (I) wherein A, B, and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

PIPERIDINE AND PYROOLIDINE COMPOUNDS

The invention relates to piperidine and pyrrolidine compounds of formula (I) wherein A, B, n and X are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

THIAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to thiazolidine derivatives of the formula (I) wherein A, B, and R1 are as described in the description, to salts, especially pharmaceutically acceptable salts, of such compounds and to their use as medicaments, especially

1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES

The invention relates to novel phenethylamide derivatives and their heterocyclic analogues of formula (I), wherein A, B, R1, R2 and R3 are as described in the application, and to the use of such compounds, or of pharmaceut

THIAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to thiazolidine derivatives of the formula (I) wherein A, B, and R1 are as described in the description, to salts, especially pharmaceutically acceptable salts, of such compounds and to their use as medicaments, especially

THIAZOLIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to novel thiazolidine derivatives of the formula (I) wherein A and R1 are as described in the description and their use as medicaments, especially as orexin receptor antagonists.