32889-74-0

Basic information

• Product Name: 3,5,6-TRICHLORO-4-HYDRAZINO-PYRIDINE-2-CARBOXYLIC ACID
• Synonyms: 3,5,6-TRICHLORO-4-HYDRAZINO-PYRIDINE-2-CARBOXYLIC ACID;4-HYDRAZINO-3,5,6-TRICHLORO-2-PYRIDINECARBOXYLIC ACID
• CAS NO: 32889-74-0
• Molecular Formula: C₆H₄Cl₃N₃O₂
• Molecular Weight: 256.47
• Mol File: 32889-74-0.mol

Chemical Properties

• Boiling Point: 378.6°Cat760mmHg
• Flash Point: 182.8°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 2.09E-06mmHg at 25°C
• CAS DataBase Reference: 3,5,6-TRICHLORO-4-HYDRAZINO-PYRIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5,6-TRICHLORO-4-HYDRAZINO-PYRIDINE-2-CARBOXYLIC ACID(32889-74-0)
• EPA Substance Registry System: 3,5,6-TRICHLORO-4-HYDRAZINO-PYRIDINE-2-CARBOXYLIC ACID(32889-74-0)

Safety Data

• Hazardous Substances Data: 32889-74-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,5,6-TRICHLORO-4-HYDRAZINO-PYRIDINE-2-CARBOXYLIC ACID is used as an intermediate in the synthesis of various pharmaceuticals for its potential applications in medicinal chemistry and drug discovery.
Used in Agrochemical Industry:
3,5,6-TRICHLORO-4-HYDRAZINO-PYRIDINE-2-CARBOXYLIC ACID is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used as an Anti-tuberculosis Agent:
3,5,6-TRICHLORO-4-HYDRAZINO-PYRIDINE-2-CARBOXYLIC ACID has shown potential as an anti-tuberculosis agent, making it a candidate for further research and development in the treatment of tuberculosis.
Used for Antimicrobial Properties:
3,5,6-TRICHLORO-4-HYDRAZINO-PYRIDINE-2-CARBOXYLIC ACID has been studied for its antimicrobial properties, indicating its potential use in combating various microbial infections.
Used in Cancer Treatment Research:
3,5,6-TRICHLORO-4-HYDRAZINO-PYRIDINE-2-CARBOXYLIC ACID has been investigated for its potential use in the treatment of cancer, highlighting its importance in the field of oncology and drug discovery.

InChI:InChI=1/C6H4Cl3N3O2/c7-1-3(12-10)2(8)5(9)11-4(1)6(13)14/h10H2,(H,11,12)(H,13,14)/p-1

Upstream product

• 1134-04-9 2,3,4,5-tetrachloro-6-(trichloromethyl)-pyridine 
• 10469-09-7 3,4,5,6-tetrachloropyridinecarboxylic acid 
• 60902-99-0 3,5,6-trichloro-4-hydrazino-pyridine-2-carbonitrile 
• 17824-83-8 3,4,5,6-tetrachloropicolinonitrile 

Downstream Products

• 40360-44-9 3,5,6-trichloropicolinic acid 
• 1702-17-6 Clopyralid 

Relevant articles and documents

REACTIONS OF POLYHALOPYRIDINES 3. REACTION OF HEPTACHLORO-2-PICOLINE WITH HYDRAZINE HYDRATE. STRUCTURE OF THE 3,5,6-TRICHLORO-4-HYDRAZINO-2-TRICHLOROMETHYLPYRIDINE MOLECULE

The reaction of heptachloropicoline with hydrazine hydrate has been studied.The formation of two isomers of hexachlorohydrazinopicoline was discovered corresponding to nucleophilic substitution at positions 2 and 4 of the pyridine ring.The structure of the isomers was determined with the aid of NMR spectroscopy and of x-ray structural analysis.

NOVEL COMPOSITIONS AND METHODS OF USE

Described herein are novel enzyme inhibitors. In some embodiments the enzyme inhibitors are integrase inhibitors, particularly HIV integrase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV integrase as a method of treating or preventing HIV, AIDS or related disorders.

Preparation of 3,6-dichloropicolinic acid

3,6-Dichloropicolinic acid is prepared by reacting 3,5,6-trichloro-4-hydrazino picolinic acid with from 2 to 3 moles of a basic reagent per mole of the picolinic acid reactant, acidifying the reaction mixture with a mineral acid and recovering the desired 3,6-dichloropicolinic acid product.

Preparation of 3,5,6-trichloropicolinic acid

3,5,6-Trichloropicolinic acid is prepared in a process which comprises A. reacting by contacting tetrachloropicolinic acid, hydrazine and an alkali reaction medium in water; B. reacting by contacting the thus formed 3,5,6-trichloro-4-hydrazinopicolinic acid intermediate with an alkali metal hydroxide and an alkaline hypochlorite solution; and C. acidifying the reaction mixture with a mineral acid and recovering the desired 3,5,6-trichloropicolinic acid product.