329010-17-5Relevant articles and documents
Cyclopropyl and cyclobutyl epothilone analogs
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Page/Page column 6; 10-11; 5/16, (2008/06/13)
The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IV wherein Ar is a radical represented by the following structure: and the other radicals and symbols have the meanings as defined herein; to their
Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues
Nicolaou,Namoto,Ritzen,Ulven,Shoji,Li,D'Amico,Liotta,French,Wartmann,Altmann,Giannakakou
, p. 9313 - 9323 (2007/10/03)
The design, chemical synthesis, and biological evaluation of a series of cyclopropyl and cyclobutyl epothilone analogues (3-12, Figure 1) are described. The synthetic strategies toward these epothilones involved a Nozaki - Hiyama - Kishi coupling to form