329946-99-8

Basic information

• Product Name: 1H-Imidazo[4,5-b]pyridin-6-amine(9CI)
• Synonyms: 1H-Imidazo[4,5-b]pyridin-6-amine(9CI);3H-IMidazo[4,5-b]pyridin-6-aMine;1H-Imidazo[4,5-b]pyridin-6-amine
• CAS NO: 329946-99-8
• Molecular Formula: C₆H₆N₄
• Molecular Weight: 134.14
• Product Categories: PYRIDINE
• Mol File: 329946-99-8.mol

Chemical Properties

• Boiling Point: 495.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.480±0.06 g/cm3(Predicted)
• PKA: 12.20±0.40(Predicted)
• CAS DataBase Reference: 1H-Imidazo[4,5-b]pyridin-6-amine(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazo[4,5-b]pyridin-6-amine(9CI)(329946-99-8)
• EPA Substance Registry System: 1H-Imidazo[4,5-b]pyridin-6-amine(9CI)(329946-99-8)

Safety Data

• Hazardous Substances Data: 329946-99-8(Hazardous Substances Data)

Usage

Chemical class

Imidazo[4,5-b]pyridine derivatives

Type of compound

Heterocyclic compound

Structural components

Imidazole ring, pyridine ring, amine group at the 6th position

Potential use

Pharmaceutical properties for medicinal purposes

Possible mode of action

Acting as a ligand or substrate for enzymes and receptors

Value in synthesis

Valuable building block for the synthesis of other biologically active compounds

Relevance in research

Promising candidate for drug discovery and development due to its chemical properties and biological activities.

Upstream product

• 3537-09-5 6-nitro-1⁽³⁾H-imidazo[4,5-b]pyridine 
• 3073-30-1 3,5-dinitropyridin-2-amine 
• 3537-14-2 5-nitro-pyridine-2,3-diamine 
• 2578-45-2 2-chloro-3,5-dinitropyridine 

Downstream Products

• 1186223-05-1 2,6-difluoro-N-(3H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonamido)benzamide 

Relevant articles and documents

Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase

This Letter details the synthesis and evaluation of imidazo[4,5-b]pyridines as inhibitors of B-Raf kinase. These compounds bind in a DFG-in, αC-helix out conformation of B-Raf, which is a binding mode associated with significant kinase selectivity. Structure-activity relationship studies involved optimization of the ATP-cleft binding region of these molecules, and led to compound 23, an inhibitor with excellent enzyme/cell potency, and kinase selectivity.

IMDIZO [4. 5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.