3537-09-5 Usage
Uses
Used in Oncology:
6-NITRO-3H-IMIDAZO[4,5-B]PYRIDINE is used as a radiosensitizer in the treatment of various types of cancer, including brain tumors, cervical cancer, and head and neck cancer. It enhances the effects of radiation therapy by increasing the sensitivity of cancer cells to radiation, leading to more effective tumor destruction.
Used in Targeting Hypoxic Tumor Cells:
6-NITRO-3H-IMIDAZO[4,5-B]PYRIDINE has been investigated for its potential to selectively target hypoxic tumor cells, which are often resistant to radiation therapy and chemotherapy. By targeting these cells, it may improve the overall effectiveness of cancer treatment.
Precautions:
6-NITRO-3H-IMIDAZO[4,5-B]PYRIDINE is also a known mutagen and genotoxic agent. Therefore, it is crucial to exercise caution during its handling and disposal to minimize potential health risks and environmental impact.
Check Digit Verification of cas no
The CAS Registry Mumber 3537-09-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,3 and 7 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3537-09:
(6*3)+(5*5)+(4*3)+(3*7)+(2*0)+(1*9)=85
85 % 10 = 5
So 3537-09-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H4N4O2/c11-10(12)4-1-5-6(7-2-4)9-3-8-5/h1-3H,(H,7,8,9)
3537-09-5Relevant academic research and scientific papers
Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase
Newhouse, Bradley J.,Wenglowsky, Steve,Grina, Jonas,Laird, Ellen R.,Voegtli, Walter C.,Ren, Li,Ahrendt, Kateri,Buckmelter, Alex,Gloor, Susan L.,Klopfenstein, Nathalie,Rudolph, Joachim,Wen, Zhaoyang,Li, Xianfeng,Feng, Bainian
, p. 5896 - 5899 (2013/10/22)
This Letter details the synthesis and evaluation of imidazo[4,5-b]pyridines as inhibitors of B-Raf kinase. These compounds bind in a DFG-in, αC-helix out conformation of B-Raf, which is a binding mode associated with significant kinase selectivity. Structure-activity relationship studies involved optimization of the ATP-cleft binding region of these molecules, and led to compound 23, an inhibitor with excellent enzyme/cell potency, and kinase selectivity.
IMDIZO [4. 5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS
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Page/Page column 53, (2009/10/22)
Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
