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Pyrazole-3-carboxamide is a chemical compound with the molecular formula C4H5N3O. It is a derivative of pyrazole, featuring a pyrazole ring with a carboxamide functional group attached to the third carbon atom. Pyrazole-3-carboxamide has garnered significant attention for its potential pharmaceutical and biological applications, characterized by its anti-inflammatory, analgesic, and antipyretic properties. Pyrazole-3-carboxamide is also under investigation as a drug target for managing pain, fever, and inflammation, and it shows promise in medicinal chemistry for the development of novel drugs and treatments.

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  • 33064-36-7 Structure
  • Basic information

    1. Product Name: Pyrazole-3-carboxamide
    2. Synonyms: 1H-Pyrazole-3-carboxamide;Pyrazole-3-carboxamide
    3. CAS NO:33064-36-7
    4. Molecular Formula: C4H5N3O
    5. Molecular Weight: 111.102
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 33064-36-7.mol
  • Chemical Properties

    1. Melting Point: 159-160 °C
    2. Boiling Point: 469.588 °C at 760 mmHg
    3. Flash Point: 237.799 °C
    4. Appearance: /
    5. Density: 1.394
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.612
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. PKA: 11.76±0.10(Predicted)
    11. CAS DataBase Reference: Pyrazole-3-carboxamide(CAS DataBase Reference)
    12. NIST Chemistry Reference: Pyrazole-3-carboxamide(33064-36-7)
    13. EPA Substance Registry System: Pyrazole-3-carboxamide(33064-36-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 33064-36-7(Hazardous Substances Data)

33064-36-7 Usage

Uses

Used in Pharmaceutical Industry:
Pyrazole-3-carboxamide is used as a pharmaceutical compound for its anti-inflammatory, analgesic, and antipyretic activities. It is being explored for the development of new drugs and treatments targeting conditions such as pain, fever, and inflammation.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, Pyrazole-3-carboxamide is used as a chemical scaffold for the design and synthesis of new drug candidates. Its diverse range of properties makes it a valuable starting point for creating innovative treatments and therapies.

Check Digit Verification of cas no

The CAS Registry Mumber 33064-36-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,0,6 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 33064-36:
(7*3)+(6*3)+(5*0)+(4*6)+(3*4)+(2*3)+(1*6)=87
87 % 10 = 7
So 33064-36-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H5N3O/c5-4(8)3-1-2-6-7-3/h1-2H,(H2,5,8)(H,6,7)

33064-36-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1H-pyrazole-5-carboxamide

1.2 Other means of identification

Product number -
Other names 1H-pyrazole-3-carboxylic acid amide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:33064-36-7 SDS

33064-36-7Relevant articles and documents

Preparation method of aromatic amide compound

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Paragraph 0068-0069, (2020/07/15)

The present invention provides a preparation method of an aromatic amide compound. In an organic solvent, under the effect of a catalyst, an aromatic acid compound and an amine source are subjected toa dehydration reaction to obtain the aromatic amide compound, wherein the aromatic acid compound is an aromatic acid, a substituted aromatic acid, a heterocyclic aromatic acid or a substituted heterocyclic aromatic acid; and the substituent group of amide is any substituent group of H, a C1-C8 straight-chain alkyl or branched-chain alkyl group, a benzene ring or an aromatic ring. The aromatic amide compound is an important chemical intermediate, and the synthesis method is mild in reaction condition and high in yield.

Corresponding amine nitrile and method of manufacturing thereof

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Paragraph 0135; 0136; 0137; 0146, (2018/05/07)

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a

Skinner, Philip J.,Cherrier, Martin C.,Webb, Peter J.,Shin, Young-Jun,Gharbaoui, Tawfik,Lindstrom, Andrew,Hong, Vu,Tamura, Susan Y.,Dang, Huong T.,Pride, Cameron C.,Chen, Ruoping,Richman, Jeremy G.,Connolly, Daniel T.,Semple, Graeme

, p. 5620 - 5623 (2008/04/02)

A series of 5-alkyl pyrazole-3-carboxylic acids were prepared and found to act as potent and selective agonists of the human GPCR, GPR109a, the high affinity nicotinic acid receptor. No activity was observed at the highly homologous low affinity niacin receptor, GPR109b. A further series of 4-fluoro-5-alkyl pyrazole-3-carboxylic acids were shown to display similar potency. One example from the series was shown to have improved properties in vivo compared to niacin.

Method of treating a patient having precancerous lesions with phenyl purinone derivatives

-

, (2008/06/13)

Derivatives of Phenyl Purinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.

PYRAZOLOPYRIMIDINONE ANTIANGINAL AGENTS

-

, (2008/06/13)

Compounds of the formula:wherein R1 is H, C1-C3 alkyl, C3-C5 cycloalkyl or C1-C3 perfluoroalkyl; R2 is H, C1-C6 alkyl optionally substituted by OH, C1-C3 alkoxy or C3-C6 cycloalkyl, or C1-C3 perfluoroalkyl; R3 is C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, C3-C7 cycloalkyl, C1-C6 perfluoroalkyl or (C3 -C6 cycloalkyl)C1-C6 alkyl; R4 taken together with the nitrogen atom to which it is attached completes a pyrrolidinyl, piperidino, morpholino, or 4-N-(R6)-piperazinyl group; R5 is H, C1-C4 alkyl, C1-C3 alkoxy, NR7 R8, or CONR7 R8 ; R6 is H, C1-C6 alkyl, (C1-C3 alkoxy) C2-C6 alkyl, hydroxy C2-C6 alkyl, (R7 R8 N)C2 -C6 alkyl, (R7 R8 NCO)C1-C6 alkyl, CONR7 R8, CSNR7 R8 or C(NH)NR7 R8 ; R7 and R8 are each independently H, C1-C4 alkyl, (C1-C3 alkoxy)C2-C4 alkyl or hydroxy C2-C4 alkyl; and pharmaceutically acceptable salts thereof, are selective cGMP PDE inhibitors useful in the treatment of cardiovascular disorders such as angina, hypertension, heart failure and atherosclerosis

Pyrazolopyrimidinone antianginal agents

-

, (2008/06/13)

Compounds of the formula STR1 and pharmaceutically acceptable salts thereof are selective cGMP PDE inhibitors which are useful in the treatment of such diseases and adverse conditions as angina, hypertension, congestive heart failure, reduced blood vessel patency, peripheral vascular disease, stroke, bronchitis, chronic asthma, allergic asthma, allergic rhinitis, glaucoma, and diseases characterized by disorders of gut motility.

Substituted pyridine compounds

-

, (2008/06/13)

Disclosed herein are herbicidal pyridine compounds substituted at the 2- or 6-position with an OR2 moiety where R2 is hydrogen, lower alkyl, halomethyl, lower cyanoalkyl, alkenyl or alkynyl, as well as herbicidal compositions and herbicidal use of these compounds.

Heterocyclic pyrazoline carboxanilides

-

, (2008/06/13)

Heterocyclic pyrazoline carboxanilide insecticides including all geometric and stereoisomers thereof, as well as agricultural compositions containing them.

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