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4-(6-Chloro-2-pyridinyl)morpholine is a heterocyclic chemical compound that belongs to the class of morpholine derivatives. It features a morpholine ring with a 6-chloro-2-pyridinyl group substitution, which endows it with unique chemical properties and potential applications in various fields.

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  • 330682-30-9 Structure
  • Basic information

    1. Product Name: 4-(6-Chloro-2-pyridinyl)morpholine
    2. Synonyms: 4-(6-Chloro-2-pyridinyl)morpholine
    3. CAS NO:330682-30-9
    4. Molecular Formula: C9H11ClN2O
    5. Molecular Weight: 198.64944
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 330682-30-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(6-Chloro-2-pyridinyl)morpholine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(6-Chloro-2-pyridinyl)morpholine(330682-30-9)
    11. EPA Substance Registry System: 4-(6-Chloro-2-pyridinyl)morpholine(330682-30-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 330682-30-9(Hazardous Substances Data)

330682-30-9 Usage

Uses

Used in Pharmaceutical Synthesis:
4-(6-Chloro-2-pyridinyl)morpholine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into drug molecules, potentially enhancing their therapeutic effects and selectivity.
Used in Agrochemical Production:
4-(6-Chloro-2-pyridinyl)morpholine is also utilized in the production of agrochemicals, where it can be used to develop new pesticides or herbicides with improved efficacy and selectivity. Its chemical properties make it a valuable building block for the creation of novel agrochemicals.
Used in Anti-inflammatory Applications:
4-(6-Chloro-2-pyridinyl)morpholine has been studied for its potential anti-inflammatory properties. It may be used as an active ingredient in anti-inflammatory drugs, helping to alleviate inflammation and related symptoms.
Used in Antifungal Applications:
Due to its potential antifungal properties, 4-(6-Chloro-2-pyridinyl)morpholine can be employed in the development of antifungal agents. It may be used to treat various fungal infections or incorporated into products to prevent fungal growth.
Used in Materials Science:
4-(6-Chloro-2-pyridinyl)morpholine may also have applications in the field of materials science. Its unique chemical structure could be used to develop new materials with specific properties, such as improved stability or reactivity.
Used in Organic Compound Production:
As an intermediate, 4-(6-Chloro-2-pyridinyl)morpholine can be employed in the production of other organic compounds. Its versatility allows it to be a valuable component in the synthesis of a wide range of organic molecules for various applications.
In all applications, it is crucial to follow proper handling and storage procedures to ensure the safe use of 4-(6-Chloro-2-pyridinyl)morpholine and minimize any potential risks associated with its chemical properties.

Check Digit Verification of cas no

The CAS Registry Mumber 330682-30-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,0,6,8 and 2 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 330682-30:
(8*3)+(7*3)+(6*0)+(5*6)+(4*8)+(3*2)+(2*3)+(1*0)=119
119 % 10 = 9
So 330682-30-9 is a valid CAS Registry Number.

330682-30-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-6-morpholine-1-ylpyridine

1.2 Other means of identification

Product number -
Other names 3-(3-chloro-2-pyridyl)morpholine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:330682-30-9 SDS

330682-30-9Relevant articles and documents

Streamlined Synthesis of Diaminopyridines by Pd-Catalyzed Ammonia Coupling with Deactivated Amino-Chloropyridines

Bourriquen, Florian,Bruneau-Voisine, Antoine,Jeandin, Aliénor,Stihle, Etienne,Fantasia, Serena

supporting information, p. 9006 - 9011 (2019/06/24)

An efficient and cost-effective two-step synthesis of diaminopyridines, fundamental building blocks of biologically active compounds, is reported. The advantages over previously reported routes include cost and wider availability of the bromo-chloropyridine starting materials and the straightforward accessibility to an extended array of diaminopyridine regioisomers. The key enabler of this synthetic strategy is the development of an unprecedented palladium-catalyzed coupling reaction of ammonia with chloropyridines deactivated by the presence of an alkylamino substituent. The coupling reaction was accomplished with very low catalyst loadings under remarkably mild reaction conditions, making the system particularly suitable for both academic and industrial applications. The utility of this methodology is exemplified by the application to the synthesis of highly relevant scaffolds, including the synthetic intermediates of the marketed drugs Ribociclib and Palbociclib.

Negishi cross-coupling reactions catalyzed by an aminophosphine-based nickel system: A reliable and general applicable reaction protocol for the high-yielding synthesis of biaryls

Gerber, Roman,Frech, Christian M.

experimental part, p. 11893 - 11904 (2011/11/29)

Treatment of NMP solutions of NiCl2 with 1,1′,1″- (phosphanetriyl)tripiperidine (≈2.05 equiv), dissolved in THF, in air at 25°C forms a highly active catalytic system for the cross-coupling of a large variety of electronically activated, non-activated, deactivated, and ortho-substituted, heterocyclic, and functionalized aryl bromides and aryl chlorides with diarylzinc reagents. Very high levels of conversion and yields were obtained within 2 h at 60°C in the presence of only 0.1 mol% of catalyst (based on nickel) and thus at catalyst loadings far lower than typically reported for nickel-catalyzed versions of the Negishi reaction. Various aryl halides-which may contain trifluoromethyl groups, fluorides, or other functional groups such as acetals, ketones, ethers, esters, lactones, amides, imines, anilines, alkenes, pyridines, quinolines, and pyrimidines-were successfully converted into the corresponding biaryls. Electronic and steric variations are tolerated in both reaction partners. Experimental observations indicate that a molecular (NiI/NiIII) mechanism is operative.

Transition metal-free amination of aryl halides-A simple and reliable method for the efficient and high-yielding synthesis of N-arylated amines

Bolliger, Jeanne L.,Frech, Christian M.

experimental part, p. 1180 - 1187 (2009/04/10)

A simple and reliable reaction protocol for the clean, fast, and high-yielding synthesis of various N-arylated amines derived from reactions of aryl halides with various (also sterically hindered) amines under transition metal-free reaction conditions is presented. Dioxane and KN(Si(CH3)3)2 were found to be the ideal solvent and base for this transformation. The conversion rates and yields observed are excellent and in the majority of the reactions performed significantly higher than that obtained in their catalyzed versions. Furthermore, the selective synthesis of 6-halopyridin-2-amines and asymmetric pyridine-2,6-diamines (derived from consecutive reactions of 2,6-dibromopyridine and 2,6-dichloropyridine, respectively, with different amines) is possible in almost quantitative yields (relative to 2,6-dihalopyridine) within very short reaction times. Purification of the 6-halopyridin-2-amine intermediates is not necessary, allowing the synthesis of pyridine-2,6-diamines in 'one-pot'. However, catalysts are in many cases not required to efficiently and selectively couple aryl halides with amines, making transition metal-free versions of the Buchwald-Hartwig reaction extremely attractive for the synthesis of N-arylated amines with substrates containing substituents on the aryl halide, which either promote regioselectivity and/or do not require regioselective aminations.

Nickel-catalysed synthesis of 3-chloroanilines and chloro aminopyridines via cross-coupling reactions of aryl and heteroaryl dichlorides with amines

Desmarets, Christophe,Schneider, Rapha?l,Fort, Yves

, p. 247 - 250 (2007/10/03)

Selective monoamination of aryl and heteroaryl dichlorides has been carried out using a catalyst combination of Ni(0) associated to 2,2′-bipyridine. The synthesis of novel 3-chloroanilines and chloro aminopyridines in good to excellent yields is allowed u

Nickel-mediated amination chemistry. Part 1: Efficient aminations of (het)aryl 1,3-di and 1,3,5-trichlorides

Desmarets, Christophe,Schneider, Rapha?l,Fort, Yves

, p. 2875 - 2879 (2007/10/03)

The first Ni-catalysed synthesis of di- and triamino substituted benzenes and diamino substituted pyridines from the corresponding aryl chlorides and amines is described. (C) 2000 Elsevier Science Ltd.

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