5140-72-7

Basic information

• Product Name: 2-BROMO-6-CHLOROPYRIDINE
• Synonyms: 2-BROMO-6-CHLOROPYRIDINE;2-Bromo-6-chloropyridine97%;2-BROMO-6-CHLOROPYRIDINE 97%;2-Chloro-6-bromopyridine;6-Chloro-2-bromopyridine;Pyridine,2-bromo-6-chloro-
• CAS NO: 5140-72-7
• Molecular Formula: C₅H₃BrClN
• Molecular Weight: 192.44
• EINECS: 225-904-4
• Product Categories: blocks;Bromides;Pyridines;Pyridine series;Pyridine;Heterocycle-Pyridine series;alkyl chloride|alkyl bromide
• Mol File: 5140-72-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 90-91 C
• Boiling Point: 230.8 °C at 760 mmHg
• Flash Point: 93.4 °C
• Appearance: /
• Density: 1.736 g/cm³
• Vapor Pressure: 0.0977mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: -3.02±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-6-CHLOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-6-CHLOROPYRIDINE(5140-72-7)
• EPA Substance Registry System: 2-BROMO-6-CHLOROPYRIDINE(5140-72-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38-41
• Safety Statements: 26-36/37-36/37/39-36/39
• WGK Germany: 1
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 5140-72-7(Hazardous Substances Data)

Usage

Chemical Properties

White crystal

InChI:InChI=1/C5H3BrClN/c6-4-2-1-3-5(7)8-4/h1-3H

Upstream product

• 40473-07-2 6-bromo-2-methoxypyridine 
• 4645-11-8 6-ethoxy-2-bromo-pyridine 
• 626-05-1 2,6-Dibromopyridine 
• 109-09-1 2-chloropyridine 
• 117068-71-0 2-(benzyloxy)-6-bromopyridine 

Downstream Products

• 4684-94-0 6-chloropicolinic acid 
• 652148-92-0 2-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 914950-09-7 2-chloro-6-ethynylpyridine 
• 1218790-96-5 6-phenyl-(2-pyridineboronic acid) 
• 110-86-1 pyridine 
• 118775-67-0 2-(6-Chloro-2-pyridyl)-1-propene 
• 7631-86-9 SiO₂ 
• 1255945-82-4 (6-chloro-pyridin-2-yl)-(2,6-difluoro-phenyl)-amine 
• 937189-11-2 4-(3,5-dimethoxy-phenyl)-2-[6-((S)-3-hydroxy-pyrrolidin-1-yl)-pyridin-2-yl]-2,5,6,7-tetrahydro-cyclopenta[d]pyridazin-1-one 
• 13382-54-2 2-chloro-6-phenyl-pyridine 
• 258506-66-0 2-chloro-5-iodo-pyridine 
• 13040-77-2 6-Chloro-[2,2']bipyridinyl 
• 263698-99-3 2-chloro-6-(tributylstannyl)pyridine 

Relevant articles and documents

Efficient and scalable synthesis of pyridine sulfonamides

Short-step and scalable transformations from 2,6-dibromopyridine to 6-bromopyridine-2-sulfonamide by means of halogen-metal exchange and subsequent reaction with sulfuryl chloride followed by amidation are established. Application of the method for the synthesis of various pyridine sulfonamides is also described. Georg Thieme Verlag Stuttgart - New York.

Synthesis of novel halopyridinylboronic acids and esters. Part 4: Halopyridin-2-yl-boronic acids and esters are stable, crystalline partners for classical Suzuki cross-coupling

This paper describes some methods for the synthesis and the isolation of novel 5 or 6-halopyridin-2-yl-boronic acids and esters 3, 4, 7. These compounds are prepared via a regioselective halogen-metal exchange using n-butyllithium and subsequent quenching with triisopropylborate starting from appropriate dihalopyridines. All substrates studied to date provided a single regioisomeric boronic acid or ester product. Additionally, these compounds have been found to undergo Pd-catalysed coupling with arylhalides and authorise a strategy to produce new pyridines libraries.