- Synthesis process of cefathiamidine
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The invention belongs to the field of medicine synthesis, and particularly relates to a synthesis process of cefathiamidine. Firstly, 1, 3-diisopropylamidino-2-thioacetic acid hydrochloride is enabledto react with p-nitrobenzenesulfonyl chloride, and then amidation reaction with 7-ACA is performed to generate cefathiamidine. The synthesis process of cefathiamidine provided by the invention is completed in one pot, the operation is simple, and the yield is obviously improved.
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Paragraph 0029; 0031-0032; 0034-0035; 0037-0038; 0040-0041
(2020/05/14)
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- Cefathiamidine preparation process
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The invention belongs to the technical field of medicine, and discloses a cefathiamidine preparation process, which comprises: carrying out silylation on 7-ACA as a raw material, carrying out a reaction with chloroacetyl chloride to form chloroacetyl 7-ACA, and carrying out a reaction with N,N-diisopropylthiourea under the action of a catalyst to form cefathiamidine. Compared with the process in the prior art, the preparation process of the present invention has characteristics of simple preparation process, less impurity content of the product, and high product purity, and is suitable for industrial production.
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Paragraph 0045-0052; 0059-0064
(2019/11/14)
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- Process for preparing cefathiamidine
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The invention discloses a preparation technology for cefathiamidine. The preparation technology specifically comprises the steps that dichloromethane and N,N'-Diisopropyl thiourea are evenly stirred, dichloromethane, acetyl bromide aminocephalosporanic acid and triethylamine are stirred and dissolved, the materials are sucked into the same reaction kettle after dissolution, a condensation reaction is carried out, then crude cefathiamidine is obtained after cooling crystallization, suction filtration washing and vacuum drying, and the crude cefathiamidine is refined through lyophilization to obtain the finished cefathiamidine. The technology is stable, the high-quality and high-purity cefathiamidine can be obtained, and the yield can reach 80.0% to 88.0%.
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Paragraph 0034-0037
(2017/02/09)
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