33075-00-2Relevant articles and documents
Synthesis process of cefathiamidine
-
Paragraph 0029; 0031-0032; 0034-0035; 0037-0038; 0040-0041, (2020/05/14)
The invention belongs to the field of medicine synthesis, and particularly relates to a synthesis process of cefathiamidine. Firstly, 1, 3-diisopropylamidino-2-thioacetic acid hydrochloride is enabledto react with p-nitrobenzenesulfonyl chloride, and then amidation reaction with 7-ACA is performed to generate cefathiamidine. The synthesis process of cefathiamidine provided by the invention is completed in one pot, the operation is simple, and the yield is obviously improved.
Process for preparing cefathiamidine
-
Paragraph 0034-0037, (2017/02/09)
The invention discloses a preparation technology for cefathiamidine. The preparation technology specifically comprises the steps that dichloromethane and N,N'-Diisopropyl thiourea are evenly stirred, dichloromethane, acetyl bromide aminocephalosporanic acid and triethylamine are stirred and dissolved, the materials are sucked into the same reaction kettle after dissolution, a condensation reaction is carried out, then crude cefathiamidine is obtained after cooling crystallization, suction filtration washing and vacuum drying, and the crude cefathiamidine is refined through lyophilization to obtain the finished cefathiamidine. The technology is stable, the high-quality and high-purity cefathiamidine can be obtained, and the yield can reach 80.0% to 88.0%.