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33075-00-2

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  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[(acetyloxy)methyl]-7-[[2-[[[(1-methylethyl)amino][(1-methylethyl)imino]methyl]thio]acetyl]amino]-8-oxo-,(6R,7R)- 33075-00-2

    Cas No: 33075-00-2

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33075-00-2 Usage

Chemical Properties

Off-White Solid

Uses

Cefathiamidine is an antibacterial agent that exhibits a broad spectrum of bactericidal activity against gram-positive bacteria.

Check Digit Verification of cas no

The CAS Registry Mumber 33075-00-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,0,7 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 33075-00:
(7*3)+(6*3)+(5*0)+(4*7)+(3*5)+(2*0)+(1*0)=82
82 % 10 = 2
So 33075-00-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H28N4O6S2/c1-9(2)20-19(21-10(3)4)31-8-13(25)22-14-16(26)23-15(18(27)28)12(6-29-11(5)24)7-30-17(14)23/h9-10,14,17H,6-8H2,1-5H3,(H,20,21)(H,22,25)(H,27,28)

33075-00-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name CEFATHIAMIDINE

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:33075-00-2 SDS

33075-00-2Downstream Products

33075-00-2Related news

Radiation induced decomposition of a refractory CEFATHIAMIDINE (cas 33075-00-2) intermediate07/14/2019

Diisopropylthiourea (DPT), an intermediate of a widely used cephalosporin, has been found to be one of the most refractory components in cephalosporin synthesis wastewater. This compound cannot be completely removed by conventional biological processes due to its antimicrobial property. Ionizing...detailed

33075-00-2Relevant articles and documents

Synthesis process of cefathiamidine

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Paragraph 0029; 0031-0032; 0034-0035; 0037-0038; 0040-0041, (2020/05/14)

The invention belongs to the field of medicine synthesis, and particularly relates to a synthesis process of cefathiamidine. Firstly, 1, 3-diisopropylamidino-2-thioacetic acid hydrochloride is enabledto react with p-nitrobenzenesulfonyl chloride, and then amidation reaction with 7-ACA is performed to generate cefathiamidine. The synthesis process of cefathiamidine provided by the invention is completed in one pot, the operation is simple, and the yield is obviously improved.

Process for preparing cefathiamidine

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Paragraph 0034-0037, (2017/02/09)

The invention discloses a preparation technology for cefathiamidine. The preparation technology specifically comprises the steps that dichloromethane and N,N'-Diisopropyl thiourea are evenly stirred, dichloromethane, acetyl bromide aminocephalosporanic acid and triethylamine are stirred and dissolved, the materials are sucked into the same reaction kettle after dissolution, a condensation reaction is carried out, then crude cefathiamidine is obtained after cooling crystallization, suction filtration washing and vacuum drying, and the crude cefathiamidine is refined through lyophilization to obtain the finished cefathiamidine. The technology is stable, the high-quality and high-purity cefathiamidine can be obtained, and the yield can reach 80.0% to 88.0%.

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