- A Modular Approach to Dibenzo-fused ?-Lactams: Palladium-Catalyzed Bridging-C?H Activation
-
Tricyclic ring systems possessing a dibenzo structure joined to a seven-membered heterocyclic ring frequently show important biological activities. However, a modular approach to these molecules based on efficient intermolecular reaction of readily available chemicals is lacking. Herein, an unprecedented palladium-catalyzed formal [4+3] annulation for modular construction of these tricyclic systems is described. This reaction features easily accessible reactants (o-haloarylaldehydes and N-tosylhydrazones), broad substrate scope, and excellent functional group compatibility. The synthetic potential is demonstrated by the easy scale-up reactions, late-stage modification of complex molecules, and collective synthesis of bioactive molecules and approved drugs.
- Huang, Xueliang,Ma, Liyao,Xia, Jiajin,Xin, Luoting,Yu, Yinghua,Zhu, Lei
-
supporting information
p. 18261 - 18266
(2020/08/21)
-
- OXYDATION OF TERTIARY POLYCYCLIC AMINES BY RuO4
-
The reactions of certain tertiary polycyclic amines such as N-benzyl-9-azabicyclo--nonane, N-benzyl-5,6-dihydro-11H-dibenzazepine, and N-benzyl-1,2,3,4-tetrahydroisoquinoline with ruthenium tetroxide, taking place in both heterogeneous and hom
- Bettoni, Giancarlo,Carbonara, Giuseppe,Franchini, Carlo,Tortorella, Vincenzo
-
p. 4159 - 4164
(2007/10/02)
-