- FUNCTIONALIZED AMINOTRIAZINES
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The present invention relates to novel antagonists of the A2B adenosine receptor and pharmaceutical compositions comprising said antagonists as well as their uses for the treatment and prevention of disorders known to be susceptible to improvement by anta
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Page/Page column 61
(2020/06/10)
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- SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF
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Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
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Page/Page column 399; 400
(2014/09/29)
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- SPIROHYDANTOIN COMPOUNDS AND THEIR USE AS SELECTIVE ANDROGEN RECEPTOR MODULATORS
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The present invention relates to a compound of formula (1-1 ) in free form or in pharmaceutically acceptable salt form in which the substituents are as defined in the specification; to its preparation, to its use as a medicament and to medicaments comprising it. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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Page/Page column 87
(2013/09/12)
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- NOVEL SPIROPIPERIDINE COMPOUNDS
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A compound of the formula: or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition, and a method for treating diabetes.
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Page/Page column 13
(2011/06/23)
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- Cyclization of propargylic amides: Mild access to oxazole derivatives
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The substrate scope, the mechanistic aspects of the gold-catalyzed oxazole synthesis, and substrates with different aliphatic, aromatic, and functional groups in the side chain were investigated. Even molecules with several propargyl amide groups could easily be converted, delivering di- and trioxazoles with interesting optical properties. Furthermore, the scope of the gold(I)-catalyzed alkylidene synthesis was investigated. Further functionalizations of these isolable intermediates of the oxazole synthesis were developed and chelate ligands can be obtained. The use of Barluenga's reagent offers a new and mild access to the synthetically valuable iodoalkylideneoxazoles from propargylic amides, this reagent being superior to other sources of halogens.
- Weyrauch, Jan P.,Hashmi, A. Stephen K.,Schuster, Andreas,Hengst, Tobias,Schetter, Stefanie,Littmann, Anna,Rudolph, Matthias,Hamzic, Melissa,Visus, Jorge,Rominger, Frank,Frey, Wolfgang,Bats, Jan W.
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supporting information; experimental part
p. 956 - 963
(2010/06/12)
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