331649-46-8

Basic information

• Product Name: 5-bromo-1H-indole-2,3-dione 3-semicarbazone
• Synonyms: 5-bromo-1H-indole-2,3-dione 3-semicarbazone
• CAS NO: 331649-46-8
• Molecular Formula: C9H7BrN4O2
• Molecular Weight: 283.08148
• Mol File: 331649-46-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-bromo-1H-indole-2,3-dione 3-semicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-1H-indole-2,3-dione 3-semicarbazone(331649-46-8)
• EPA Substance Registry System: 5-bromo-1H-indole-2,3-dione 3-semicarbazone(331649-46-8)

Safety Data

• Hazardous Substances Data: 331649-46-8(Hazardous Substances Data)

Upstream product

• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 4426-72-6 hydrazine carboxamide 
• 563-41-7 semicarbazide hydrochloride 

Relevant articles and documents

Manganese(II) complexes of biological relevance: Synthesis and spectroscopic characterization of novel manganese(II) complexes with monobasic bidentate ligands derived from halo-substituted 1H-indole-2,3-diones

Novel biologically significant manganese(II) complexes with four monobasic bidentate ligands L1H [2-(5-fluoro-2-dihydro-2-oxo-1H-indol-3-ylidene)hydrazinecarboxamide], L2H [2-(5-fluoro-2-dihydro-2-oxo-1H-indol-3-ylidene)hydrazinecarbothioamide], L3H [2-(5-bromo-2-dihydro-2-oxo-1H-indol-3-ylidene)hydrazinecarboxamide] and L4H [2-(5-bromo-2-dihydro-2-oxo-1H-indol-3-ylidene)hydrazinecarbothioamide] were synthesized by complexation of the ligands with MnCl2·4H2O in 1: 1 and 1: 2 molar ratios in methanol. The Schiff base ligands and complexes were characterized by elemental analyses, melting points, molecular weights, IR, 1H and 13C NMR, UV–Vis, EPR, and mass spectra, as well as X-ray powder diffraction patterns. Based on the spectral data, a tetrahedral geometry was proposed for all the synthesized metal complexes. The ligands and complexes were tested in vitro against bacteria (Escherichia coli and Staphylococcus aureus) and fungi (Fusarium semitectum and Aspergillus flavus) to show that they were active against all the microbial strains examined, and the metal complexes were more active in comparison with the ligands. DNA cleavage activity of the complexes was examined by gel electrophoresis.

One-pot multicomponent synthesis of novel 2-(piperazin-1-yl) quinoxaline and benzimidazole derivatives, using a novel sulfamic acid functionalized Fe3O4 MNPs as highly effective nanocatalyst

The immobilization of sulfonic acid on the surface of Fe3O4 magnetic nanoparticles (MNPs) as a novel acid nanocatalyst has been successfully reported. The morphological features, thermal stability, magnetic properties, and other physicochemical properties of the prepared superparamagnetic core–shell (Fe3O4@PFBA–Metformin@SO3H) were thoroughly characterized using Fourier transform infrared (FTIR), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS), field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), thermogravimetric analysis–differential thermal analysis (TGA-DTA), atomic force microscopy (AFM), dynamic light scattering (DLS), Brunauer–Emmett–Teller (BET), and vibrating sample magnetometer (VSM) techniques. It was applied as an efficient and reusable catalyst for the synthesis of 2-(piperazin-1-yl) quinoxaline and benzimidazole derivatives via a one-pot multiple-component cascade reaction under green conditions. The results displayed the excellent catalytic activity of Fe3O4@PFBA–metformin@SO3H as an organic–inorganic hybrid nanocatalyst in condensation and multicomponent Mannich-type reactions. The easy separation, simple workup, excellent stability, and reusability of the nanocatalyst and quantitative yields of products and short reaction time are some outstanding advantages of this protocol.