Amine compounds, their production and use as amyloid-β production inhibitors
A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2—, (iii) C1-6alkylene, C2-6alkeny
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(2008/06/13)
Synthesis of Mannich bases as spermicidal agents
A number of β-aminoketones have been synthesised by reaction of pyrrolidine/piperidine/piperazine/4-methylpiperidine/morpholine with 6-methoxy-tetralone (1)/5-methoxy-1-indanone(2)/6-ketoestradiol-17β-acetate 3-methyl ether (3) under Mannich reaction conditions. The Mannich bases 8, 9, 12, 13 on reduction give the corresponding hydroxy compounds (16-19). All the compounds have been screened for their spermicidal activity. Compounds 4 and 14 show spermicidal activity at 0.1 and 0.5% concentrations, respectively in Sander Cramer's assay.
Studies on the Amine Exchange Reactions in C-Mannich Bases
Amine exchange reactions are extended to C-Mannich bases derived from 6-methoxy-1-tetralone and the reaction intermediate during exchange reaction was isolated and characterised.
Kulkarni, Y. D.,Agarwal, Vipin Kumar
p. 380 - 382
(2007/10/02)
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