- Synthesis and stability of novel terminal phosphate-labeled nucleotides
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Novel compounds consisting of a nucleotide triphosphate labeled with a PEG linker and various terminal groups attached to the γ-phosphate of the nucleotide were constructed for use in efforts to produce a new class of DNA sequencer. The stability of these novel compounds was investigated to determine their utility as sequencing reagents. Hydrolysis rate constants were measured for both the natural nucleoside triphosphate dATP and novel dATP derivatives. The γ-labeled dATP was approximately 20-fold more stable to hydrolysis than dATP. Copyright Taylor & Francis Group, LLC.
- Reynolds, Bambi,Miller, Rachel,Williams, John G.,Anderson, Jon P.
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- BIS(2-HALOACETAMIDO)-COMPOUNDS FOR USE AS LINKING AGENTS AND RESULTANT PRODUCTS WHICH COMPRISE ANTIBODIES, HALF-ANTIBODIES AND ANTIBODY FRAGMENTS
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Bis(2-haloacetamido)- compounds for use as linkers to chemically cross-linking multiple thiol groups, and particularly, although not exclusively, the thiol groups of cysteine amino acids in peptide chains are described, along with their use as linking age
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- Bivalent HIV-1 fusion inhibitors based on peptidomimetics
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Membrane fusion is a valid target for inhibition of HIV-1 replication. A 34-mer fragment peptide (C34), which is contained in the HIV-1 envelope protein gp41, has significant anti-HIV activity. Previously, a dimeric derivative of C34 linked by a disulfide bridge at its C-terminus was found to have more potent anti-HIV activity than the C34 peptide monomer. To date, several peptidomimetic small inhibitors have been reported, but most have lower potency than peptide derivatives related to C34. In the present study we applied this dimerization concept to these peptidomimetic small inhibitors and designed several bivalent peptidomimetic HIV-1 fusion inhibitors. The importance of the length of linkers crosslinking two peptidomimetic compounds was demonstrated and several potent bivalent inhibitors containing tethered peptidomimetics were produced.
- Kobayakawa, Takuya,Ebihara, Kento,Tsuji, Kohei,Kawada, Takuma,Fujino, Masayuki,Honda, Yuzuna,Ohashi, Nami,Murakami, Tsutomu,Tamamura, Hirokazu
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- Selective inhibition of human brain tumor cells through multifunctional quantum-dot-based siRNA delivery
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(Figure Presented) More than one Job: Quantum dots (QDs) conjugated with thiol-modified small Interfering RNA (siRNA) were functlonalized with thiol-modlfied RGD and HIV-Tat peptides. These multifunctional QDs were used for the targeted delivery and track
- Jung, Jongjin,Solanki, Aniruddh,Memoli, Kevin A.,Kamei, Ken-Ichiro,Kim, Hiyun,Drahl, Michael A.,Williams, Lawrence J.,Tseng, Hsian-Rong,Lee, Kibum
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supporting information; experimental part
p. 103 - 107
(2010/03/30)
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