- Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts
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Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPIV)2 (PIV = COtBu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.
- Sanagawa, Atsushi,Nagashima, Hideo
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supporting information
p. 287 - 291
(2019/01/10)
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- Preparation method and application of functionalized column [5] arene trimer
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The invention discloses a preparation method and application of functionalized column [5] arene trimer. The functionalized column [5] arene trimer is well synergistic in host-guest interaction, the preparation method of the functionalized column [5] arene trimer is a chemical synthetic process, and a product is obtained by subjecting p-methoxybenzene and paraformaldehyde as starting materials to catalytic and synthetic reactions. The materials of the product are simple and easily obtainable, the method is simple to perform, and reaction conditions are mild. In cationic molecular recognition for linear diamine hydrochlorides and branched triamine hydrochlorides, it is possible for significant charge transfer to occur, very characteristic absorption peaks are shown in ultraviolet, and the trimer is applicable to ultraviolet detection.
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Paragraph 0015; 0016
(2017/03/14)
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- Synthesis of poly(galactaramides) from alkylene- and substituted alkylenediammonium galactarates
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Polyhydroxypolyamides (PHPAs) represent a class of synthetic polyamides derived from aldaric acid and diamine monomer units. This paper describes the synthesis of some poly(galactaramides), a class of polyhydroxypolyamides, that employs alkylene and subst
- Kiely, Donald E.,Vishwanathan, Arvind,Jarman, Bevan P.,Manley-Harris, Merilyn
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experimental part
p. 348 - 368
(2010/01/16)
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- Tricyclic nitrogen ring compounds, their production and use
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Tricyclic compound of the formula: STR1 wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.
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- 1,4-Diaminobutanes from furans: A new synthetic approach to substituted putrescines
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A novel approach for the synthesis of (hydroxymethyl)- and (aminomethyl)-putrescines starting with furanmethanols and aminomethyl- furanmethanols is reported. The furans were converted to their 2,5-dimethoxy- tetrahydrofuran derivatives and the latter were ring-opened in acid media. The resulting carbonyl derivatives were isolated as their dioximes and the latter were then reduced to the corresponding amino alcohols.
- Frydman, Benjamin,Ojea, Maria I.
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p. 4765 - 4768
(2007/10/03)
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- Curtius rearrangement of ω-azido acid chlorides: Access to the corresponding ω-azido substituted amines and carbamates, useful building blocks for polyamine syntheses
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Treatment of ω-azido acid chlorides with trimethylsilyl azide affords ω-azido isocyanates which can be easily converted in good yields to the corresponding ω-azidoamines or ω-azidocarbamates. 1,3- and 1,4-diamine dihydrochlorides can then be prepared by catalytic hydrogenation or reductive alkylation with an organodichloroborane.
- Khoukhi, Mostafa,Vaultier, Michel,Benalil, Aziza,Carboni, Bertrand
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p. 483 - 487
(2007/10/03)
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- The stereochemistry of the enzymic decarboxylation of L-arginine and L-ornithine
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The decarboxylation of L-ornithine to yield putrescine, catalyzed by the L-ornithine decarboxylase (EC 4.1.1.17) of E. coli, and the decarboxylation of L-arginine to yield agmatine, catalyzed by the L-arginine decarboxylase (EC 4.1.1.19) of E. coli, take place with retention of configuration.
- Richards, James C.,Spenser, Ian D.
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p. 2810 - 2820
(2007/10/02)
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