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333-93-7 Usage

Chemical Properties

white powder


Putrescine dihydrochloride has been used as medium component in F-12 + GlutaMax medium for mice ganglia culture, retinal ganglion cell culture and in HCT116 colon carcinoma cells for ornithine decarboxylase (ODC) assay.

General Description

Putrescine is an end product of fatty acid metabolism in dead tissues. It is a volatile diamine with pungent odour. It is synthesized by the decarboxylation of ornithine in the presence of enzyme, ornithine decarboxylase. Molecular docking studies reveal the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), present in olfactory epithelium.

Biochem/physiol Actions

Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.

Purification Methods

Crystallise the salt from EtOH/H2O. [Beilstein 4 IV 1284.]

Check Digit Verification of cas no

The CAS Registry Mumber 333-93-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,3 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 333-93:
57 % 10 = 7
So 333-93-7 is a valid CAS Registry Number.

333-93-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (D0081)  1,4-Diaminobutane Dihydrochloride  >98.0%(T)

  • 333-93-7

  • 25g

  • 470.00CNY

  • Detail
  • TCI America

  • (D0081)  1,4-Diaminobutane Dihydrochloride  >98.0%(T)

  • 333-93-7

  • 500g

  • 3,490.00CNY

  • Detail
  • Alfa Aesar

  • (A18312)  1,4-Diaminobutane dihydrochloride, 99%   

  • 333-93-7

  • 25g

  • 557.0CNY

  • Detail
  • Alfa Aesar

  • (A18312)  1,4-Diaminobutane dihydrochloride, 99%   

  • 333-93-7

  • 100g

  • 1213.0CNY

  • Detail
  • Sigma

  • (P7505)  Putrescinedihydrochloride  ≥98% (TLC)

  • 333-93-7

  • P7505-25G

  • 735.93CNY

  • Detail
  • Sigma

  • (P7505)  Putrescinedihydrochloride  ≥98% (TLC)

  • 333-93-7

  • P7505-100G

  • 2,253.42CNY

  • Detail
  • Sigma-Aldrich

  • (32810)  1,4-Diaminobutanedihydrochloride  purum, ≥99.0% (AT)

  • 333-93-7

  • 32810-25G

  • 741.78CNY

  • Detail
  • Sigma-Aldrich

  • (32810)  1,4-Diaminobutanedihydrochloride  purum, ≥99.0% (AT)

  • 333-93-7

  • 32810-100G

  • 2,614.95CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017


1.1 GHS Product identifier

Product name 1,4-Diaminobutane dihydrochloride

1.2 Other means of identification

Product number -
Other names 1,4-DIAMINOBUTANE 2HCL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:333-93-7 SDS

333-93-7Relevant articles and documents

Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts

Sanagawa, Atsushi,Nagashima, Hideo

supporting information, p. 287 - 291 (2019/01/10)

Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPIV)2 (PIV = COtBu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.

Synthesis of poly(galactaramides) from alkylene- and substituted alkylenediammonium galactarates

Kiely, Donald E.,Vishwanathan, Arvind,Jarman, Bevan P.,Manley-Harris, Merilyn

experimental part, p. 348 - 368 (2010/01/16)

Polyhydroxypolyamides (PHPAs) represent a class of synthetic polyamides derived from aldaric acid and diamine monomer units. This paper describes the synthesis of some poly(galactaramides), a class of polyhydroxypolyamides, that employs alkylene and subst

1,4-Diaminobutanes from furans: A new synthetic approach to substituted putrescines

Frydman, Benjamin,Ojea, Maria I.

, p. 4765 - 4768 (2007/10/03)

A novel approach for the synthesis of (hydroxymethyl)- and (aminomethyl)-putrescines starting with furanmethanols and aminomethyl- furanmethanols is reported. The furans were converted to their 2,5-dimethoxy- tetrahydrofuran derivatives and the latter were ring-opened in acid media. The resulting carbonyl derivatives were isolated as their dioximes and the latter were then reduced to the corresponding amino alcohols.

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