- Preparation method of 3-hydroxy-4-methoxyphenylpropylaldehyde
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The invention provides a preparation method of 3-hydroxy-4-methoxyphenylpropylaldehyde. The preparation method comprises the following steps: 1, ring opening: subjecting sassafras oil, methanol and an alkaline reagent to a reaction to obtain a phenol potassium salt solution; 2, etherification: subjecting the phenol potassium salt solution to reacting with an excessive methylation reagent to obtain mixed ether; 3, hydrolysis: subjecting the mixed ether to reacting with alcohol, water and a catalyst to obtain a hydrolyzed oil phase; 4, esterification: subjecting the hydrolyzed oil phase to reacting with acetic anhydride to obtain an acetyl intermediate product; 5, ozonization and reduction: subjecting the acetyl product to reacting with ozone, and adding a pyrosulfite solution for reduction to obtain a reduced oil phase; 6, alcoholysis: performing alcoholysis on the oil phase obtained in the step 5 to obtain a crude isovanillin product; 7, condensation; and 8, hydrogenation. The preparation method solves the problems that isovanillin is few in source and high in price, and production of a 3-hydroxy-4-methoxyphenylpropyl aldehyde intermediate is limited in the prior art, and has the advantages of being high in yield and low in cost.
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Paragraph 0048; 0057-0058; 0067-0068; 0077-0078; 0087-0088
(2021/11/10)
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- Crystals of aspartame derivative
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N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester useful as a sweetener with a high potency of sweetness, is provided in the crystalline form having a high stability and a good purity which is favorable as a commercia
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- Process for producing cinnamaldehyde derivatives, use thereof and the like
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A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in
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- Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof
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The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes.
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