- Desulfitative cross-coupling of protecting group-free 2-thiouracil derivatives with organostannanes
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We here report a unique and efficient copper bromide mediated pallado-catalyzed coupling of protecting group-free 2-thiouracil derivatives with organostannanes. The nature of the copper appears to be crucial for successful cross coupling.
- Sun, Qi,Suzenet, Franck,Guillaumet, Gerald
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supporting information; experimental part
p. 3473 - 3476
(2010/08/06)
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- Angiotensin II receptor antagonistic 1,2,4-triazin-5-one derivatives
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Disclosed are novel 1,2,4-triazin-5-one biphenyl derivatives having structural formula (I) useful as non-peptide antagonists of angiotensin II receptor: where R1 represents alkyl, cycloalkyl, or substituted or unsubstituted aryl; R2 represents alkyl, substituted or unsubstituted aryl, or arylalkyl; A and D independently represent C-R3, N, NH or C=O, wherein when A and D independently denote C-R3 or N, b and c are independently a double bond, and when A and D independently denote NH or C=O, b and c are independently a single bond; provided that b and c are not both double bonds; and R3 is hydrogen, dialkylphosphonate or halogen; and pharmaceutically acceptable salts thereof. Also disclosed is the use of the compounds of formula (I) as non-peptide antagonists of angiotensin II receptor, in the treatment of cardiovascular diseases, in particular hypertension and congestive heart failure.
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- 1,2,4-Triazines. II. New Zwitterionic Methylation Products of Some 1,2,4-Triazin-5(2H)-ones and Their Identification by Carbon-13 Nuclear Magnetic Resonance Spectroscoy
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The methylation of various 3- and 6-substituted 1,2,4-triazin-5(2H)-one derivatives yield new zwitterionic N 1 methylation products in addition to the previously reported 2-, 4- and O-methyl isomers.Specifically, 3-phenyl-1,2,4-triazin-5(2H)-one and its 6
- Jacobsen, Noel W.,Rose, Stephen E.
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p. 967 - 975
(2007/10/02)
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- STUDIES ON as-TRIAZINE DERIVATIVES. IV. SYNTHESIS OF UNSYMMETRICAL 5,6-DISUBSTITUTED 1,2,4-TRIAZINES
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The reaction of 5-chloro-6-methyl-3-phenyl-1,2,4-triazine (4a) with ethylidenetriphenylphosphorane followed by the hydrolysis of the resulting as-triazinylphosphorane afforded 5-ethyl-6-methyl-3-phenyl-1,2,4-triazine (6a) in 88 percent yield.The condensat
- Konno, Shoetsu,Sagi, Mataichi,Agata, Mitsuko,Aizawa, Yuichi,Yamanaka, Hiroshi
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p. 2241 - 2244
(2007/10/02)
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