334620-16-5Relevant articles and documents
R - 3 - amino - hexahydro nitrogen heterocyclic heptane hydrochloride of a new synthesis method
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, (2018/09/08)
The invention discloses R - 3 - amino - hexahydro nitrogen heterocyclic heptane hydrochloride of a new synthesis method, the present invention the R - 3 - amino - hexahydro nitrogen heterocyclic heptane hydrochloride prepared by the method of the preparation of R - 3 - amino - hexahydro nitrogen heterocyclic heptane hydrochloride of high yield, after treatment is simple, its high stereoselectivity, racemic probability is small. In addition to the reaction of the starting material, the reagent (methanol, dichloromethane, toluene sulfonyl chloride, ammonia and the like) are commonly used reagents, simple and easy to obtain, the price is cheap, the cost effectiveness of the; reaction in each step are only the low-temperature or room temperature reaction, mild condition, high-temperature to reduce the impact of the three-dimensional configuration; each step in the reaction yield is relatively high, the after-treatment can be conducted by using re-crystallization, greatly improves the efficiency of the purification.
A kind of optical active pharmaceutical process for the preparation of intermediates
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Paragraph 0071; 0072, (2016/10/17)
The invention relates to a preparation method of an optical active compound, represented by formula I, or a hydrochloride of the optical active compound by taking a compound with optical activity as a starting material. Raw materials of the preparation method are cheap and easily available; no splitting is needed; the whole technological operation is simple and convenient; cost is low; pollution on environment is less; and the preparation method is suitable for industrialized production. In the formula I, n is 1 or 2 or 3.
