334952-09-9

Basic information

• Product Name: 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID
• Synonyms: RARECHEM AL BO 0984;OXINDOLE-6-CARBOXYLIC ACID;2,3-DIHYDRO-2-OXO-1H-INDOLE-6-CARBOXYLIC ACID;2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID;6-OXINDOLECARBOXYLIC ACID;6-CARBOXYOXINDOLE;2-Oxo-indoline-6-carboxylic acid;2,3-Dihydro-2-oxo-1H-indole-6-carboxylic acid97%
• CAS NO: 334952-09-9
• Molecular Formula: C₉H₇NO₃
• Molecular Weight: 177.16
• Product Categories: blocks;Carboxes;IndolesOxindoles;pharmacetical;Indoline & Oxindole
• Mol File: 334952-09-9.mol

Chemical Properties

• Boiling Point: 438.1 °C at 760 mmHg
• Flash Point: 218.8 °C
• Appearance: /
• Density: 1.433 g/cm³
• Vapor Pressure: 1.89E-08mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.94±0.20(Predicted)
• CAS DataBase Reference: 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID(334952-09-9)
• EPA Substance Registry System: 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID(334952-09-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 334952-09-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID is used as a key building block in the synthesis of various pharmaceuticals and organic compounds. Its unique structure and functional groups make it a valuable component in the development of new drugs and therapeutic agents.
Used in Anti-inflammatory Applications:
In the medical field, 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID is used as an anti-inflammatory agent for its potential to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
Used in Anti-cancer Applications:
2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID is used as an anti-cancer agent, showing promise in the treatment of various types of cancer. Its ability to target and inhibit the growth of cancer cells makes it a potential candidate for further research and development in oncology.
Used in Anti-microbial Applications:
In the field of microbiology, 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID is used as an anti-microbial agent, demonstrating effectiveness against certain bacteria and other microorganisms. This property makes it a candidate for the development of new antimicrobial drugs and treatments.
Used in Neurodegenerative Disease Treatment:
2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID is used in the research and potential treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's, due to its potential neuroprotective effects and ability to modulate relevant signaling pathways.
Used in Mental Disorder Treatment:
In the field of psychiatry, 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID is used in the study and potential treatment of mental disorders, given its potential to modulate neurotransmitter systems and exhibit anxiolytic and antidepressant-like effects.
Used in Organic Synthesis Industry:
2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID is used as a versatile intermediate in the organic synthesis industry for the development of various chemical compounds and materials, leveraging its reactivity and functional groups for diverse applications.

InChI:InChI=1/C9H7NO3/c11-8-4-5-1-2-6(9(12)13)3-7(5)10-8/h1-3H,4H2,(H,10,11)(H,12,13)

Upstream product

• 14192-26-8 2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester 
• 101870-10-4 2,3-dicarbonylindolone-6-carboxylic acid 
• 99-05-8 meta-aminobenzoic acid 
• 121-92-6 3-nitrobenzoic acid 
• 618-95-1 methyl 3-nitrobenzoate 
• 334952-07-7 4-methoxycarbonylmethyl-3-nitrobenzoic acid methyl ester 
• 954239-49-7 2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid ethyl ester 
• 501-89-3 4-(carboxymethyl)benzoic acid 
• 444667-11-2 2-(4-carboxy-2-nitrophenyl)-acetic acid 

Downstream Products

• 1401461-12-8 N-(1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)pyrrolidin-3-yl)-2-oxoindoline-6-carboxamide 

Relevant articles and documents

Method for preparing methyl 2-carbonyloxindole-6-carboxylate

The invention relates to a novel method for preparing methyl 2-carbonyloxindole-6-carboxylate. The method has the advantages of simple processes, high yield and mass production.

OXINDOLE INHIBITORS OF TYROSINE KINASE

The present invention relates to new oxindole inhibitors of tyrosine kinase, pharmaceutical compositions thereof, and methods of use thereof.

Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors

A series of N-benzylated isatin oximes were developed as inhibitors of the mitogen-activated kinase, JNK3. X-ray crystallographic structures aided in the design and synthesis of novel, selective compounds, that inhibit JNK3, but not p38 MAP kinase and provided key insights into understanding the behavior of gatekeeper residue methionine-146 in determining target selectivity for this series.

NOVEL HYDROXYINDOLE DERIVATIVE

A compound or a pharmaceutically acceptable salt thereof of the present invention is represented by the following general formula (I): [wherein, R1 to R8 may have a hydrogen atom, a halogen atom, a hydroxy group, a C1-C6 alkyl group,

INDOLINONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS

The invention relates to indolinone compounds of formula (I), wherein Y and R1 to R8 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.

Multicyclic bis-amide MMP inhibitors

The present invention relates generally to bis-amide group containing pharmaceutical agents, and in particular, to multicyclic bis-amide MMP-13 inhibitor compounds. More particularly, the present invention provides a new class of MMP-13 inhibiting compounds, containing a pyrimidinyl bis-amide group in combination with a heterocyclic moiety, that exhibit an increased potency and solubility in relation to currently known bis-amide group containing MMP-13 inhibitors.

Substituted indolines which inhibit receptor tyrosine kinases

Indolinones of the formula having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumor cells. Exemplary are: (a) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-ethoxycarbonyl-2-indolinone, (b) 3-Z-[(1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-carbamoyl-2-indolinone, and (c) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-metboxycarbonyl-2-indolinone.