444667-11-2

Usage

Uses

Used in Pharmaceutical Industry:
4-(Carboxymethyl)-3-nitrobenzoic acid is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its acidic and electron-withdrawing properties make it a valuable component in the development of new drugs, contributing to their chemical structures and potential therapeutic effects.
Used in Dye Industry:
In the dye industry, 4-(Carboxymethyl)-3-nitrobenzoic acid is utilized as a chemical intermediate in the production of different types of dyes. Its unique chemical properties allow for the creation of dyes with specific characteristics, such as color intensity and stability.
Used in Organic Synthesis:
4-(Carboxymethyl)-3-nitrobenzoic acid is used as a building block in the synthesis of more complex organic molecules. Its reactivity, due to the presence of the nitro group, makes it a versatile component in organic chemistry, facilitating the formation of a wide range of compounds for various applications.
Used in Chemical Reactions:
The reactivity of 4-(Carboxymethyl)-3-nitrobenzoic acid, particularly due to its nitro group, makes it useful in certain chemical reactions. It can participate in reduction, substitution, and other reaction types, allowing for the modification of its structure to achieve desired properties or functionalities in the final products.

InChI:InChI=1/C9H7NO6/c11-8(12)4-5-1-2-6(9(13)14)3-7(5)10(15)16/h1-3H,4H2,(H,11,12)(H,13,14)

Upstream product

• 651747-69-2 2-(4-cyano-2-nitrophenyl)malonic acid dimethyl ester 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 76469-88-0 methyl 4-(cyanomethyl)benzoate 
• 89642-49-9 4-bromo-3-nitrobenzonitrile 
• 501-89-3 4-(carboxymethyl)benzoic acid 

Downstream Products

• 334952-07-7 4-methoxycarbonylmethyl-3-nitrobenzoic acid methyl ester 
• 334952-09-9 2-Oxo-2,3-dihydro-1H-indole-6-carboxylic acid 
• 96-98-0 4-methyl-3-nitrobenzoic acid 
• 124-38-9 carbon dioxide 
• 444667-12-3 t-Butyl α-[4-(t-butoxycarbonyl)-2-nitrophenyl]-acetate 
• 444667-13-4 tert-butyl α-bromo-α-(4-tert-butoxycarbonyl-2-nitrophenyl)acetate 
• 444667-15-6 O-[α,4-bis-(t-butoxycarbonyl)-2-nitrobenzyl]-acetic acid 
• 444667-16-7 4-O-(α,4-dicarboxy-2-nitrobenzyl) aspartate 
• 444667-14-5 4-O-[α,4-bis(tert-butoxycarbonyl)-2-nitrobenzyl] 1-O-(tert-butyl) (R)-N-(tert-butoxycarbonyl)aspartate 
• 19013-11-7 4-methyl-3-nitrobenzamide 

Relevant academic research and scientific papers

Multicyclic bis-amide MMP inhibitors

The present invention relates generally to bis-amide group containing pharmaceutical agents, and in particular, to multicyclic bis-amide MMP-13 inhibitor compounds. More particularly, the present invention provides a new class of MMP-13 inhibiting compounds, containing a pyrimidinyl bis-amide group in combination with a heterocyclic moiety, that exhibit an increased potency and solubility in relation to currently known bis-amide group containing MMP-13 inhibitors.

Synthesis and photophysical characterization of a new, highly hydrophilic caging group

o-Nitrobenzyl-protected bioactive compounds are useful tools in biophysics, allowing controlled photorelease of biologically active compounds with high temporal and spatial precision. Thus, it is possible to study biological processes, such as neurotransmitter-receptor interaction, and many other processes, in much more detail than before. In this respect, these caged compounds have become established as extremely useful tools. In some cases, however, their biological properties (the caged compound should not interact with the biological system), their photochemical properties (quantum yield and kinetics of the photorelease), and their physical properties (high hydrophilicity) are not satisfactory. In order to address the last problem, we examined means to increase the hydrophilicity of caged compounds based on the o-nitrobenzyl moiety. Here, we report the synthesis and the photochemical and biological characterization of a new caged Daspartate derivative with vastly improved hydrophilicity, compared to derivatives reported previously, and satisfactory photophysical properties. Caged compounds with this improved o-nitrobenzyl group may thus represent a valuable new tool for different kinds of biophysical investigations. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.