335451-22-4

Basic information

• Product Name: 4-Nitro-1-(triisopropylsilyl)indole
• Synonyms: 4-Nitro-1-(triisopropylsilyl)indole
• CAS NO: 335451-22-4
• Molecular Formula: C17H26N2O2Si
• Molecular Weight: 318
• Mol File: 335451-22-4.mol

Chemical Properties

• Boiling Point: 357.6±24.0 °C(Predicted)
• Appearance: /
• Density: 1.06±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 4-Nitro-1-(triisopropylsilyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro-1-(triisopropylsilyl)indole(335451-22-4)
• EPA Substance Registry System: 4-Nitro-1-(triisopropylsilyl)indole(335451-22-4)

Safety Data

• Hazardous Substances Data: 335451-22-4(Hazardous Substances Data)

Upstream product

• 4769-97-5 4-nitro-1H-indoIe 
• 13154-24-0 triisopropylsilyl chloride 

Relevant articles and documents

Synthesis of a Series of Diaminoindoles

A selection of 3,4-diaminoindoles were required for a recent drug discovery project. To this end, a 10-step synthesis was developed from 4-nitroindole. This synthesis was subsequently adapted and used to synthesize 3,5-; 3,6-; and 3,7-diaminoindoles from

Preparation and reactions of 4-, 5-, and 6-methoxy substituted 3-lithioindoles and 3-indolylzinc derivatives

The preparation of 4-, 5-, and 6-methoxy substituted 3-lithio-1-(trialkylsilyl)indoles 4b-d by metalation of the corresponding 3-bromoindoles, and their reactions with iodomethane, DMF, ethylene oxide and aziridines are reported. Transmetalation of 3-lithioindoles 4b-d with ZnCl2 afforded 3-indolylzinc chlorides 11b-d, which underwent Pd(0)-catalyzed cross-coupling reactions with 2-halopyridines to give 4-, 5-, and 6-methoxy substituted 3-(2-pyridyl)indoles.