4769-97-5

Basic information

• Product Name: 4-Nitroindole
• Synonyms: 4-NITROINDOLE;4-NITRO-1H-INDOLE;4-Nitorindole;Nitroindole,4-;4-Nitroindole 97%;4-NITROINDOLE 98+%;1H-Indole, 4-nitro-;4-Nitro-1H-indole 97%
• CAS NO: 4769-97-5
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.15
• EINECS: 1806241-263-5
• Product Categories: blocks;IndolesOxindoles;NitroCompounds;Indoles and derivatives;Indole;Indole Derivatives;Indoles;Simple Indoles;Building Blocks;Heterocyclic Building Blocks;Heterocyclic Building Blocks;Heterocycle-Indole series
• Mol File: 4769-97-5.mol
• Article Data: 29

Chemical Properties

• Melting Point: 205-207 °C(lit.)
• Boiling Point: 288.82°C (rough estimate)
• Flash Point: 173.1 ºC
• Appearance: Yellow/Granular Powder
• Density: 1.3264 (rough estimate)
• Vapor Pressure: 3.98E-05mmHg at 25°C
• Refractive Index: 1.5770 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Acetone, Dichloromethane, Ethyl Acetate, Methanol
• PKA: 14.76±0.30(Predicted)
• BRN: 136022
• CAS DataBase Reference: 4-Nitroindole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitroindole(4769-97-5)
• EPA Substance Registry System: 4-Nitroindole(4769-97-5)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 68
• Safety Statements: 45-36/37-24/25
• WGK Germany: 3
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• Hazardous Substances Data: 4769-97-5(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Crystalline Solid

Uses

Different sources of media describe the Uses of 4769-97-5 differently. You can refer to the following data:
1. 4-Nitroindole is an intermediate for the preparation of indole compounds useful in treatment of pain, inflammation.
2. 4-Nitroindole was used in the synthesis of 1,3,4,5-tetrahydropyrrolo-[4,3,2-de]quinoline.

InChI:InChI=1/C8H6N2O2/c11-10(12)8-3-1-2-7-6(8)4-5-9-7/h1-5,9H

Synthetic route

→ 4-nitro-1H-indoIe (4769-97-5)

4-nitro-1H-indole-3-carbaldehyde (10553-11-4) → 4-nitro-1H-indoIe (4769-97-5)

Conditions	Yield
With hydrogenchloride In methanol for 1.5h; Heating;	99%

methyl 2-hydroxy-2-(4-nitroindol-1-yl)-acetate (81038-27-9) → 4-nitro-1H-indoIe (4769-97-5)

Conditions	Yield
With sodium hydrogencarbonate In methanol; water for 0.0833333h; Heating;	94.5%

methyl 2-(4-nitroindole-1-yl)oxyacetate (81038-26-8) → 4-nitro-1H-indoIe (4769-97-5)

Conditions	Yield
With triethylamine In methanol for 16h; Ambient temperature;	94.3%

2,6-dinitrostyrene (195992-08-6) → 4-nitro-1H-indoIe (4769-97-5)

Conditions	Yield
With triphenylphosphine; palladium diacetate In acetonitrile under 3040 Torr; for 26h; Heating;	89%
With carbon monoxide; palladium diacetate; triphenylphosphine In acetonitrile at 90℃; under 3051.25 Torr; for 50h;	89%

4-nitro-1H-indole-3-carbaldehyde (10553-11-4) + sodium cyanide (143-33-9) → 4-nitro-1H-indoIe (4769-97-5) + 4-nitro-3-indoleacetonitrile (4770-06-3) + N-(4-nitroindol-3-yl)methylformamide

Conditions	Yield
With sodium tetrahydroborate In methanol; formamide at 100℃; for 5h;	A 2% B 88% C 9%

1-hydroxy-4-nitroindole (78283-23-5) + ethyl bromoacetate (105-36-2) → 4-nitro-1H-indoIe (4769-97-5) + methyl 2-hydroxy-2-(4-nitroindol-1-yl)-acetate (81038-27-9) + methyl 2-(4-nitroindole-1-yl)oxyacetate (81038-26-8)

Conditions	Yield
With triethylamine In methanol for 43h; Ambient temperature;	A 59.2% B 20% C 14.4%
With triethylamine In methanol Product distribution; Ambient temperature; different reaction time;

3-nitro-trans-2-[β-(dimethylamino)vinyl]-nitrobenzene (78283-21-3) → 4-amino-1H-indole (5192-23-4) + 4-nitro-1H-indoIe (4769-97-5) + 1-hydroxy-4-nitroindole (78283-23-5) + 1-hydroxy-4-nitrooxyindole (78283-24-6)

Conditions	Yield
With titanium(III) chloride In water; acetic acid for 0.116667h; Ambient temperature;	A 2.8% B 13.1% C 56.8% D 15.9%
With titanium(III) chloride In methanol for 0.116667h; Ambient temperature;	A 3.6% B 31.3% C 47.3% D 5.6%
With titanium(III) chloride In N,N-dimethyl-formamide for 0.116667h; Product distribution; Ambient temperature; investigation of the synthesis and stability of the 4-substituted 1-hydroxy-indoles;	A 41.8% B 6.3% C 21.9% D 1.3%

potassium cyanide (151-50-8) + 4-nitrogramine (7150-46-1) → 4-nitro-1H-indoIe (4769-97-5) + 4-nitro-3-indoleacetonitrile (4770-06-3)

Conditions	Yield
In water; N,N-dimethyl-formamide for 1.5h; Heating;	A 9.9% B 55.9%
In water; N,N-dimethyl-formamide for 2h; Heating;	A 24.6% B 50.7%

1-(4-nitro-1H-indol-3-yl)ethan-1-one (4769-95-3) → 4-nitro-1H-indoIe (4769-97-5)

Conditions	Yield
With palladium diacetate; trifluoroacetic acid at 100℃; for 4h;	52%

1-hydroxy-4-nitroindole (78283-23-5) + ethyl bromoacetate (105-36-2) → 4-nitro-1H-indoIe (4769-97-5) + methyl 2-(4-nitroindole-1-yl)oxyacetate (81038-26-8)

Conditions	Yield
With triethylamine In methanol for 16h; Ambient temperature;	A 40.7% B 50.8%

4-amino-1H-indole (5192-23-4) → 4-nitro-1H-indoIe (4769-97-5) + 7-hydroxy-4-nitroindole (135531-91-8) + 5-hydroxy-4-nitroindole (135531-89-4)

Conditions	Yield
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane; acetone for 0.583333h; pH 9;	A 32% B 5% C 16%
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane; acetone for 0.166667h; pH 9;	A 28% B 3% C 20%

ethyl N-(2-methyl-3-nitrophenyl)formimidate (115118-93-9) + oxalic acid diethyl ester (95-92-1) → 4-nitro-1H-indoIe (4769-97-5) + (4-nitroindol-3-yl)-2-oxoacetic acid (90947-20-9) + ethyl (4-nitroindol-3-yl)-2-oxoacetate (91974-30-0) + methyl (4-nitroindol-3-yl)-2-oxoacetate (115118-95-1)

Conditions	Yield
With potassium ethoxide In diethyl ether; ethanol Heating; Title compound not separated from byproducts;	A 10% B 30% C n/a D n/a

3-nitro-trans-2-[β-(dimethylamino)vinyl]-nitrobenzene (78283-21-3) → 4-nitro-1H-indoIe (4769-97-5) + 1-hydroxy-4-nitroindole (78283-23-5)

Conditions	Yield
With hydrogen; palladium on activated charcoal In tetrahydrofuran for 1h;	A 9% B 27%

4-amino-1H-indole (5192-23-4) → 4-nitro-1H-indoIe (4769-97-5) + 4-nitrosoindole + 5-hydroxy-4-nitroindole (135531-89-4)

Conditions	Yield
With phosphate buffer; 3-chloro-benzenecarboperoxoic acid In dichloromethane; acetone for 0.583333h; Product distribution; various reagents, additives (pH), solvents and times;	A 15% B 21% C 14%
With phosphate buffer; 3-chloro-benzenecarboperoxoic acid In dichloromethane; acetone for 0.583333h; pH 7;	A 15% B 21% C 14%

4-nitro-1H-indole-2-carboxylic acid (16732-60-8) → 4-nitro-1H-indoIe (4769-97-5)

Conditions	Yield
With quinoline; copper(II) oxide

methanol (67-56-1) + 4-nitro-1H-indole-3-carbaldehyde (10553-11-4) → 4-nitro-1H-indoIe (4769-97-5) + 4-nitro-3-indoleacetonitrile (4770-06-3) + 3-methoxymethyl-4-nitroindole

Conditions	Yield
With sodium tetrahydroborate; sodium cyanide 1.) 18 deg C, 1 h, 2.) reflux, 5 h; Yield given. Multistep reaction. Yields of byproduct given;

methanol (67-56-1) + 4-nitrogramine methiodide (23099-33-4) → 4-nitro-1H-indoIe (4769-97-5) + 3-methoxymethyl-4-nitroindole + 4-nitrobrassinin + methyl (4-nitroindol-3-ylmethyl)dithiocarbamate

Conditions	Yield
With pyridine; carbon disulfide; ammonium hydroxide; triethylamine; methyl iodide Yield given. Multistep reaction. Yields of byproduct given;

4-nitro-1H-indole-3-carbaldehyde (10553-11-4) + sodium cyanide (143-33-9) → 4-nitro-1H-indoIe (4769-97-5) + 4-nitro-3-indoleacetonitrile (4770-06-3) + 3-methoxymethyl-4-nitroindole

Conditions	Yield
With methanol; sodium tetrahydroborate 1.) 18 deg C, 1 h, 2.) reflux, 5 h; Yield given. Multistep reaction. Yields of byproduct given;

4-nitrogramine methiodide (23099-33-4) → 4-nitro-1H-indoIe (4769-97-5) + 4-nitroindole-3-methanamine + 3-methoxymethyl-4-nitroindole + bis(4-nitroindol-3-ylmethyl)amine

Conditions	Yield
With methanol; ammonium hydroxide for 2h; Heating; Yield given. Yields of byproduct given;

acetaldehyde-(3-nitro-phenylhydrazone) (23622-32-4) → 6-nitroindole (4769-96-4) + 4-nitro-1H-indoIe (4769-97-5)

Conditions	Yield
GIPKh-115 In acetonitrile at 200 - 320℃; (g) phase;
GIPKh-115 In acetonitrile at 180 - 320℃; (g) phase. Object of study: effect of electronic factors;

4-nitro-1H-indoIe (4769-97-5) → 4-amino-1H-indole (5192-23-4)

Conditions	Yield
palladium In ethanol	100%
With sodium tetrahydroborate In water at 20℃; for 1h;	100%
With hydrogen In ethanol at 20℃; under 760.051 Torr; for 4h;	99%

4-nitro-1H-indoIe (4769-97-5) + ethyl bromoacetate (105-36-2) → (4-nitro-indol-1-yl)-acetic acid ethyl ester (594844-55-0)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 36h;	100%

o-fluorobenzyl bromide (446-48-0) + 4-nitro-1H-indoIe (4769-97-5) → C15H11FN2O2

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 3.15h;	100%

4-nitro-1H-indoIe (4769-97-5) + 1-(Bromomethyl)-3-fluorobenzene (456-41-7) → C15H11FN2O2

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 3.15h;	100%

4-nitro-1H-indoIe (4769-97-5) + 4-Fluorobenzyl bromide (459-46-1) → C15H11FN2O2

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 3.15h;	100%

4-nitro-1H-indoIe (4769-97-5) + 2-methylbenzyl bromide (89-92-9) → C16H14N2O2

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 3.15h;	100%

4-nitro-1H-indoIe (4769-97-5) + 1-bromomethyl-3-methyl-benzene (620-13-3) → C16H14N2O2

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 3.15h;	100%

4-nitro-1H-indoIe (4769-97-5) + 4-Methylbenzyl bromide (104-81-4) → C16H14N2O2

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 3.15h;	100%

4-nitro-1H-indoIe (4769-97-5) + 1,3-diphenylprop-2-yn-1-yl acetate (93321-44-9) → 3-(1,3-diphenylprop-2-ynyl)-4-nitro-1H-indole

Conditions	Yield
With indium(III) chloride In acetonitrile at 20℃; for 3h;	99%
With iodine In dichloromethane at 20℃; for 24h;	79%

4-nitro-1H-indoIe (4769-97-5) + methyl iodide (74-88-4) → 1-methyl-4-nitro-1H-indole (91482-63-2)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide for 2h; cooling;	98%
Stage #1: 4-nitro-1H-indoIe With sodium hydride In N,N-dimethyl-formamide Cooling with ice; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 4h;	95%
Stage #1: 4-nitro-1H-indoIe With potassium hydroxide In acetone at 0℃; Stage #2: methyl iodide In acetone at 20℃; for 2h;	85.14%

4-nitro-1H-indoIe (4769-97-5) + trifluoroacetic acid-methyl ester (431-47-0) → 1-methyl-4-nitro-1H-indole (91482-63-2)

Conditions	Yield
Stage #1: 4-nitro-1H-indoIe With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.0833333h; Stage #2: trifluoroacetic acid-methyl ester In N,N-dimethyl-formamide; mineral oil for 4h;	98%

4-nitro-1H-indoIe (4769-97-5) + methyl 2-oxo-2-(pyrrolidin-1-yl)acetate (41600-21-9) → methyl (4-nitroindol-3-yl)-2-oxoacetate (115118-95-1)

Conditions	Yield
With pyrophosphoryl chloride at 0 - 20℃; Vilsmeier glyoxylation;	97%
With pyrophosphoryl chloride at 20℃; for 3h;	63%
Stage #1: 4-nitro-1H-indoIe; methyl 2-oxo-2-(pyrrolidin-1-yl)acetate With pyrophosphoryl chloride at 20℃; Cooling with ice; Stage #2: With methanol; sodium hydrogencarbonate In water at 0℃;	15%

4-nitro-1H-indoIe (4769-97-5) + acetyl chloride (75-36-5) → 1-(4-nitro-1H-indol-3-yl)ethan-1-one (4769-95-3)

Conditions	Yield
With aluminum (III) chloride; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride	97%
With aluminium trichloride; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride at 20℃; Friedel-Crafts acylation;	87%

4-nitro-1H-indoIe (4769-97-5) + benzenesulfonyl chloride (98-09-9) → 4-nitro-1-(phenylsulfonyl)-1H-indole (850655-62-8)

Conditions	Yield
Stage #1: 4-nitro-1H-indoIe With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: benzenesulfonyl chloride In N,N-dimethyl-formamide at 0 - 20℃; Stage #3: With water; ammonium chloride In N,N-dimethyl-formamide	97%
Stage #1: 4-nitro-1H-indoIe With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.333333h; Inert atmosphere; Stage #2: benzenesulfonyl chloride In tetrahydrofuran for 1h; Inert atmosphere;	95%
Stage #1: 4-nitro-1H-indoIe With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 1h; Inert atmosphere; Stage #2: benzenesulfonyl chloride In tetrahydrofuran; mineral oil for 1h; Inert atmosphere;	95%

4-nitro-1H-indoIe (4769-97-5) + rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene (87751-69-7) → C23H18N2O2 (1304665-66-4)

Conditions	Yield
With amberlyst-15 In acetonitrile at 20℃; for 8h;	97%

4-nitro-1H-indoIe (4769-97-5) + benzyl bromide (100-39-0) → 1-benzyl-4-nitro-1H-indole (81038-29-1)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; benzene for 17h;	96.8%
Stage #1: 4-nitro-1H-indoIe With sodium hydride In N,N-dimethyl-formamide Cooling with ice; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 4h;	93%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; Inert atmosphere; Schlenk technique;	62%

4-nitro-1H-indoIe (4769-97-5) + 4-Fluorobenzenesulfonyl chloride (349-88-2) → 1-(4'-fluorobenzenesulfonyl)-4-nitro-1H-indole (1131453-08-1)

Conditions	Yield
With potassium hydroxide In tetrahydrofuran at 25 - 30℃;	96.44%

4-nitro-1H-indoIe (4769-97-5) + N-(chloromethyl)dimethylamine (30438-74-5) → 4-nitrogramine (7150-46-1)

Conditions	Yield
In acetic acid	96%

4-nitro-1H-indoIe (4769-97-5) → 1-methyl-4-nitro-1H-indole (91482-63-2)

Conditions	Yield
	96%

4-nitro-1H-indoIe (4769-97-5) + carbonic acid dimethyl ester (616-38-6) → 1-methyl-4-nitro-1H-indole (91482-63-2)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 2h; Green chemistry;	96%

4-nitro-1H-indoIe (4769-97-5) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-nitro-1H-indole-1-carboxylate (913836-24-5)

Conditions	Yield
dmap In dichloromethane at 0 - 20℃;	95%
dmap In toluene at 20℃; for 1.75h; Product distribution / selectivity;	95.8%
With triethylamine In dichloromethane at 0℃; for 2h;	71%

4-nitro-1H-indoIe (4769-97-5) + methyl chloroformate (79-22-1) → 1-methoxycarbonyl-4-nitroindole (81038-41-7)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide for 4h;	95.1%
With sodium hydride	93%

4-nitro-1H-indoIe (4769-97-5) + cyclopropylcarbinyl bromide (7051-34-5) → 1-cyclopropylmethyl-4-nitro-1H-indole (1262797-29-4)

Conditions	Yield
Stage #1: 4-nitro-1H-indoIe With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Stage #2: cyclopropylcarbinyl bromide In N,N-dimethyl-formamide; mineral oil	95%

4-nitro-1H-indoIe (4769-97-5) + L-serin (56-45-1) → 4-nitro-1-tryptophan

Conditions	Yield
With Pf2A6 enzyme In aq. phosphate buffer; water; dimethyl sulfoxide at 75℃; for 12h; pH=8; Reagent/catalyst; Enzymatic reaction;	95%
With tryptophan synthase from Salmonella typhimurium cell lysate In aq. phosphate buffer at 37℃; for 72h; pH=7.4; Enzymatic reaction;

4-nitro-1H-indoIe (4769-97-5) + 2-(4-bromobutyl)isoindoline-1,3-dione (5394-18-3) → 2-(4-(4-nitro-1H-indol-1-yl)butyl)isoindoline-1,3-dione (882032-51-1)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 86℃; for 23h;	94.5%

4-nitro-1H-indoIe (4769-97-5) + oxalic acid diethyl ester (95-92-1) → 1-ethyl-4-nitro-1H-indole (91482-64-3)

Conditions	Yield
With potassium ethoxide In N,N-dimethyl-formamide Heating;	94%

Upstream product

• 4769-95-3 1-(4-nitro-1H-indol-3-yl)ethan-1-one 
• 135531-92-9 5-methoxy-4-nitroindole 
• 51516-96-2 3-nitrophenylhydrazine hydrochloride 
• 162659-19-0 N-(2-methyl-3-nitrophenyl)methylenimine 
• 134747-25-4 ethyl 2-[2-(3-nitrophenyl)hydrazinylidene]propanoate 
• 4993-93-5 4-nitro-1H-indole-2-carboxylic acid ethyl ester 
• 77759-08-1 2-(2,6-dinitrophenyl)ethanol 
• 52536-99-9 1-(2-chloroethyl)-2,6-dinitrobenzene 
• 93213-74-2 2-(bromomethyl)-1,3-dinitrobenzene 
• 606-20-2 2,6-dinitrotoluene 
• 603-83-8 3-nitro-o-tolylamine 
• 122-51-0 orthoformic acid triethyl ester 
• 10553-11-4 4-nitro-1H-indole-3-carbaldehyde 
• 77287-34-4 formamide 

Downstream Products

• 827607-93-2 5-methyl-4-nitro-1-phenylsulfonylindole 
• 10553-07-8 7-methyl-4-nitro-1H-indole 
• 61149-54-0 5-methyl-4-nitroindole 
• 118452-13-4 1-<2-Deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl>-4-nitro-1H-indole 
• 91482-63-2 1-methyl-4-nitro-1H-indole 
• 81038-28-0 4-nitro-1-tosyl-1H-indole 
• 81038-41-7 1-methoxycarbonyl-4-nitroindole 
• 7150-46-1 4-nitrogramine 
• 126496-87-5 (S)-2-Benzyloxycarbonylamino-3-(4-nitro-1H-indol-3-yl)-propionic acid benzyl ester 
• 81038-29-1 1-benzyl-4-nitro-1H-indole 
• 133053-95-9 1,3-bis(trifluoroacetyl)-2-(4-nitro-3-indolyl)-4-imidazoline 
• 852042-23-0 1-(3,5-dimethyl-phenyl)-4-nitro-1H-indole 
• 4769-95-3 1-(4-nitro-1H-indol-3-yl)ethan-1-one 
• 335451-22-4 4-Nitro-1-(triisopropylsilyl)indole 

Relevant articles and documents

Synthesis of model chromophores related to the gold fluorescent protein (GdFP)

The two model chromophores 2 and 3 for the core 1 of the gold fluorescent protein (GdFP) were synthesized from commercially available 2-methyl-3- nitroaniline (4) in six synthetic steps and overall yields of 13% and 8%, respectively. The key step of the sequence is the chemoselective, reductive introduction of the amino group after assembly of the Z-configured 5-(indol-3-ylmethylene)imidazolin-4-one skeleton of the chromophore. Compound (Z)-2 was shown to undergo a light-initiated E/Z-isomerization, which allows access also to its E-isomer. Georg Thieme Verlag Stuttgart.

A medicine intermediate 4 - nitro indole preparation process (by machine translation)

The present invention discloses a pharmaceutical intermediate 4 - nitro indole preparation process, which belongs to the field of pharmaceutical intermediates. The invention relates to 2 - methyl - 3 - nitroaniline with the original carboxylic acid triethyl ester as raw material, in the sulfonic acid type cation exchange resin and common under the catalysis of the sodium tartrate, for 95 - 105 °C lower, reaction generating N - (2 - methyl - 3 - nitrophenyl) b [...] imine, N - (2 - methyl - 3 - nitrophenyl) b oxygen radical armor imine with strong alkali and diethyl oxalate phosphite to produce 4 - nitro indole. The invention two-step process of 4 - nitro indole, intermediate does not need purification, simplifies the process, and avoiding the loss of the product; at the same time the process of the invention, simple post-treatment, the product has high purity, the purification process of product loss, high yield. (by machine translation)

A indole compound and its preparation method and application (by machine translation)

The invention discloses a indole compound and its preparation method and application. The indole compounds of the structural formula such as formula (I) is shown. The indoles, rice galenical demonstrate the excellent inhibitory activity, the effect of most of the compound is obviously better than the positive control drug validamycin; especially compound I - 43, I - 44, I - 54, I - 73, II - 7 and II - 17, its galenical very good living body protection and treating effect, effect is better than the positive control; more specifically, compound I - 43 of the rice sheath blight bacteriostatic activity than validamycin activity is improved by nearly 300 times. The indole compounds in the prevention and/or treatment of rice sheath blight has great application prospects. In addition the compound of the invention is simple in construction, the preparation method is simple, and is suitable for large-scale industrial production. (I). (by machine translation)