337512-14-8

Basic information

• Product Name: 3-OXO-2-(2-PHENYLHYDRAZONO)-3-(2-THIENYL)PROPANAL
• Synonyms: 3-OXO-2-(2-PHENYLHYDRAZONO)-3-(2-THIENYL)PROPANAL;(2E)-3-oxo-2-(2-phenylhydrazin-1-ylidene)-3-(thiophen-2-yl)propanal
• CAS NO: 337512-14-8
• Molecular Formula: C₁₃H₁₀N₂O₂S
• Molecular Weight: 258.3
• Mol File: 337512-14-8.mol

Chemical Properties

• Melting Point: 113-114 °C(Solv: ethanol (64-17-5))
• Boiling Point: 418.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• PKA: 6.46±0.10(Predicted)
• CAS DataBase Reference: 3-OXO-2-(2-PHENYLHYDRAZONO)-3-(2-THIENYL)PROPANAL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OXO-2-(2-PHENYLHYDRAZONO)-3-(2-THIENYL)PROPANAL(337512-14-8)
• EPA Substance Registry System: 3-OXO-2-(2-PHENYLHYDRAZONO)-3-(2-THIENYL)PROPANAL(337512-14-8)

Safety Data

• Hazardous Substances Data: 337512-14-8(Hazardous Substances Data)

Upstream product

• 34772-98-0 (2E)-3-(dimethylamino)-1-thien-2-ylprop-2-en-1-one 
• 100-34-5 benzene diazonium chloride 
• 62-53-3 aniline 

Downstream Products

• 936132-87-5 3-oxo-2-(phenylhydrazono)-3-(thien-2-yl)-propionitrile 
• 1051983-35-7 3-hydrazono-2-phenylhydrazono-1-(thiophen-2-yl)propan-1-one 
• 1055324-49-6 2-phenyl-6-(thiophene-2-carbonyl)-2,3-dihydropyridazine-4-carbonitrile 
• 390375-72-1 1,6-Dihydro-1-phenyl-3-(2-thienoyl)pyridazine-5,6-dicarboxydihydrazide 
• 390375-69-6 Dimethyl 1,6-dihydro-1-phenyl-3-(2-thienoyl)pyridazine-5,6-dicarboxylate 

Relevant articles and documents

Arylhydrazonals as the aldehyde component in Baylis-Hillman reactions

Arylhydrazonals were added to acrylonitrile or methyl vinyl ketone in the presence of DABCO or benzotriazole to yield the intermediate Baylis-Hillman adduct that cyclized under the reaction conditions with water elimination to yield dihydropyridazines. A pyridazine reacted with DMAD to yield a pyridine via a [4+2] Diels-Alder addition followed by retro Diels-Alder elimination of methylene aniline. Two pyridazines were condensed with DMFDMA to yield the corresponding enaminones that reacted with NH2NH2 to afford the pyrazolylpyridazines.

Substituted hydrazonals as building blocks in heterocyclic synthesis: A new route to arylhydrazonocinnolines

2-heteroylhydrazonopropanals 2a-e and 3-oxo-2-arylhydrazonopropanals 2f-k were prepared via coupling of enaminones 1 with aromatic diazonium salts. Compounds 2a-c condensed with hydrazine hydrate to yield the corresponding hydrazones 3a-c which afford on

Efficient synthesis of 3-aroylcinnolines from aryl methyl ketones

An efficient synthesis of 3-aroylcinnolines starting from the appropriate aryl methyl ketones is described. The latter were converted in two steps to the corresponding 3-oxo-3-aryl-2-arylhydrazonopropanals, which upon acid catalyzed cyclization in conc. s

Studies with functionally substituted heteroaromatics: A novel route for the synthesis of 1-aryl-6-oxopyridazinones, 1-arylpyridazine-6-imines and 1-aryl-6-imino-4-pyridazinals

Aryldiazonium salts couple with the 3-dimethylamino-1-substituted enones 1 a-c to yield 2-arylhydrazono-3-oxo-3-substituted-propanals which are excellent precursors for the synthesis of pyridazinones. The coupling reaction of 2-cyano-5-dimethylamino-3-substituted-penta-2,4-dienonitrile 12 a-b with benzene diazonium salts in ethanolic sodium hydroxide gives the pyridazinals 13a,b.