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100-34-5 Usage

Chemical Properties

Ionic salt. Very soluble in water; insoluble in most organic solvents.


Dye intermediate.


Highly toxic. Can explode on heating.

Safety Profile

Potentially explosive when dry.Potentially explosive reaction with potassium omethyldithiocarbonate.When heated to decomposition itemits toxic fumes of Cl- and NOx.

Check Digit Verification of cas no

The CAS Registry Mumber 100-34-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 0 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 100-34:
15 % 10 = 5
So 100-34-5 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name benzenediazonium,chloride

1.2 Other means of identification

Product number -
Other names Benzenediazonium chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100-34-5 SDS

100-34-5Relevant articles and documents



, p. 844,851,853 (1903)


Synthesis, in vitro and in Silico studies of some novel 5-nitrofuran-2-yl hydrazones as antimicrobial and antitubercular agents

Abdel-Aziz, Hatem Abdel-Kader,Eldehna, Wagdy Mohamed,Fares, Mohamed,Elsaman, Tilal,Abdel-Aziz, Marwa Mostafa,Soliman, Dalia Hussein

, p. 1617 - 1630 (2015)

In this study, we synthesized two series of novel 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e in addition to a third series of thiophene-2-carbohydrazides 23a-g to develop potent antimicrobial and/or antitubercular agents. The newly synthesized compounds were evaluated in vitro for their antimicrobial and antimycobacterial activities. Most of the 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e displayed variable activity against Aspergillus fumigates, Staphylococcus aureus, Streptococcus pneumonia, Bacillis subtilis, Salmonella typhimurium, Klebsiella pneumonia, Escherichia coli and Mycobacterium tuberculosis. The sulfonamide derivative 21f exhibited superior potency and broad-spectrum antimicrobial activity with minimum inhibitory concentration (MIC)=0.06-0.98 μg/mL and antimycobacterial activity with MIC=3.9 μg/mL. The 5-nitrofuran-2-carbohydrazides 21a, b, g, h and 22a-c exhibited significant antibacterial activity with MIC values in the range of 0.12-7.81 μg/mL. The significances of the 5-nitrofuran moiety and sulfonamide function were explored via the structure-activity relationship (SAR) study. In addition, docking studies revealed that the p-amino benzoic acid (PABA) and binding pockets of the dihydropteroate synthase (DHPS) were successfully occupied by compound 21f. Furthermore, two quantitative structure-activity relationship (QSAR) models were built to explore the structural requirements which controlled the activity.

Tetracyclic compounds from 1-oxo-1,2,3,4,5,6-hexahydrocycloocta[b]indole. Synthesis of oxazolo[4′5′:8,7]cycloocta[b]indoles

Vandana,Velumani,Prasad, K. J. Rajendra

, p. 299 - 306 (2003)

Japp-Klingmann method was used to diazotise aniline derivatives and 2-hydroxymethylenecyclooctanone 2 to obtain cyclooctan-1′,2′ -dione-1′-arylhydrazone 3 which upon acid cyclisation using kents reagent gave 1-oxo-1,2,3,4,5,6-hexahydrocycloocta[b]indole 4


, p. 4251,4252 (1952)

Electrochemical investigations of some newly synthesized arylazapyrazole derivatives

Arshad, Nasima,Ikramullah,Aamir, Muhammad,Sher, Muhammad

, p. 245 - 255 (2017)

Abstract: Three derivatives of arylazapyrazole ((E)-4-(phenyldiazenyl)-3,5-dimethyl-1H-pyrazole, (E)-4-[(4-fluorophenyl)diazenyl]-3,5-dimethyl-1H-pyrazole, and (E)-4-[(4-iodophenyl)diazenyl]-3,5-dimethyl-1H-pyrazole) were synthesized, characterized, and further investigated for their electrochemical behavior at glassy carbon electrode using cyclic voltammetry. All compounds were reduced following Ei Ci mechanism giving single cathodic peak in potential range 0 to ?2?V vs. Ag/AgCl. The plots of log iP vs. log ν showed that the electrode process is mixed adsorption-diffusion controlled. The kinetic parameters such as transfer coefficient (αn), diffusion coefficients (Do), and standard heterogeneous rate constants (ks) were determined from the electrochemical data. The values of Do were determined and found greater for the smallest among the three compounds. ks values were calculated by Laviron formalism which lies in the order of 10?2?s?1. Temperature and pH effects were studied and thermodynamic parameters such as change in free energy of activation (ΔG#), apparent activation energy (Ea), enthalpy (ΔH#), and entropy (ΔS#) of activation were determined. Negative values of Ea, ΔH#, and ΔS# imply that the electrode process needs lesser over potential with temperature rise, pre-adsorption of the analyte onto the electrode surface and the activated complex has a more organized structure than the reactants, respectively. Graphical abstract: [Figure not available: see fulltext.]

Polymer complexes. LXX. Synthesis, spectroscopic studies, thermal properties and antimicrobial activity of metal(II) polymer complexes

Morgan, Sh. M.,El-Sonbati,El-Mogazy

, (2018)

The monomer 3-allyl-5-(phenylazo)-2-thioxothiazolidine-4-one (HL) was prepared by the reaction of allyl rhodanine with aniline through diazo-coupling reaction. Reaction of HL with Ni(II) or Co(II) salts gave polymer complexes (1–8) with general stoichiome

New Thiophene Derivatives as Antimicrobial Agents

Mabkhot, Yahia Nasser,Kaal, Nahed Ahmed,Alterary, Seham,Mubarak, Mohammad S.,Alsayari, Abdulrhman,Bin Muhsinah, Abdullatif

, p. 2845 - 2953 (2019)

Phenacylbromide derivatives constitute a multilateral group of precursors for the synthesis of numerous heterocycles of organic compounds. Briefly, 5-(2-bromo-acetyl)-substituted-thiophene derivative has been used as a synthon for synthesis of new thiophene-containing compounds through the reaction with nucleophilic nitrogen compounds and thioamides. The suggested structures of the newly synthesized thiophene compounds were confirmed and assured with different spectroscopic tools and with CHN elemental analysis. Additionally, the antimicrobial activity of these thiophene compounds was recorded to investigate their potency against various types of bacteria and fungi. Results showed that these compounds exhibit significant inhibitory activity against the growth of tested bacterial and fungal strains and that some derivatives were more potent than the employed reference drugs.

Synthesis and antimicrobial activity of substituted 4-aryl-3-phenylhydrazono-2,4-dioxobutanoic acids


, p. 424 - 426 (1999)


Selective Formation of Products of Interrupted Feist-Benary Reaction under the Conditions of Hantzsch Pyrrole Synthesis


, p. 799 - 801 (2018)

Reaction of 3-aryl-2-chloropropanal with 1-arylsulfonylpropan-2-ones in aqueous ammonia and alcohol under the conditions of Hantzsch pyrrole synthesis led to the selective formation of the products of interrupted Feist-Benary reaction, 2-(R-benzyl)-4-aryl

Design, synthesis, and molecular docking study of novel heterocycles incorporating 1,3,4-thiadiazole moiety as potential antimicrobial and anticancer agents

El-Naggar, Mohamed,Sallam, Hanan A.,Shaban, Safaa S.,Abdel-Wahab, Salwa S.,Amr, Abd El-Galil E.,Azab, Mohammad E.,Nossier, Eman S.,Al-Omar, Mohamed A.

, (2019)

A new series of 5-(3,5-dinitrophenyl)-1,3,4-thiadiazole derivatives were prepared and evaluated for their in vitro antimicrobial, antitumor, and DHFR inhibition activity. Compounds 9, 10, 13, and 16 showed strong and broad-spectrum antimicrobial activity comparable to Amoxicillin and Fluconazole as positive antibiotic and antifungal controls, respectively. Compounds 6, 14, and 15 exhibited antitumor activity against four human cancer cell lines, CCRF-CEM leukemia, HCT-15 colon, PC-3 prostate, and UACC-257 melanoma cell lines using Doxorubicin as a reference drug. Compounds 10, 13, 14, and 15 proved to be the most active DHFR inhibitors with an IC50 range of 0.04 ± 0.82–1.00 ± 0.85 μM, in comparison with Methotrexate (IC50 = 0.14 ± 1.38 μM). The highly potent DHFR inhibitors shared a similar molecular docking mode and made a critical hydrogen bond and arene?arene interactions via Ser59 and Phe31 amino acid residues, respectively.



, p. 198,205-207 (1937)


Preparation method of monocyclic or polycyclic compound containing pyrrole ring


Paragraph 0028-0030; 0031-0032, (2021/05/15)

The invention discloses a preparation method of a monocyclic or polycyclic compound containing a pyrrole ring. An enamine compound is used as a raw material and is continuously subjected to diazotization, reduction and cyclization synthesis with a carbony

Synthetic method for preparing 5-aminobenzimidazolone


Paragraph 0016; 0031-0033; 0042-0044, (2021/07/17)

The invention discloses a synthesis method for preparing 5-aminobenzimidazolone (TM), which comprises the following steps: firstly, carrying out diazotization reaction on aniline to prepare aniline diazonium salt; secondly, coupling the aniline diazonium salt with o-phenylenediamine to generate an azo compound, and carrying out a reaction on the azo compound and urea under the catalysis of concentrated sulfuric acid to generate an azobenzimidazolone compound, and subjecting the azobenzimidazolone compound to a hydrogenation reduction reaction to obtain the target compound 5-aminobenzimidazolone. The method disclosed by the invention is simple in process, high in selectivity and high in product yield, all used reactants are utilized, and the method has very high atom economy. The use of a nitration reagent concentrated nitric acid is avoided, the wastewater and the generation of salt in the wastewater are greatly reduced, and the method is a green production process. In addition, the hydrocracking reduction operation is simple, no other iron mud such as iron powder reduction is generated, no waste residue is basically generated, the quality of a finished product is obviously improved, filter-pressing rinsing water can be repeatedly used for more than multiple times, the cost is reduced, and the environmental pollution is reduced.

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