338978-29-3

Basic information

• Product Name: 1-(4-([5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL)-1-ETHANONE
• Synonyms: 1-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)ethanone;1-[4-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]ethanone;1-[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]ethanone;1-(4-([5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL)-1-ETHANONE
• CAS NO: 338978-29-3
• Molecular Formula: C14H10F3NO2
• Molecular Weight: 281.23
• Mol File: 338978-29-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-([5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL)-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-([5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL)-1-ETHANONE(338978-29-3)
• EPA Substance Registry System: 1-(4-([5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL)-1-ETHANONE(338978-29-3)

Safety Data

• Hazardous Substances Data: 338978-29-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-([5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL)-1-ETHANONE is used as an intermediate in the synthesis of pharmaceuticals for its unique chemical structure and properties. Its ability to be incorporated into various drug molecules makes it a valuable component in the development of new medications.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-([5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL)-1-ETHANONE is used as an intermediate in the synthesis of agrochemicals. Its specific chemical features allow it to be a part of the development process for new compounds that can be used in agriculture to improve crop protection and yield.

Upstream product

• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 99-93-4 4-Hydroxyacetophenone 

Relevant articles and documents

Design, Synthesis, and Herbicidal Activity of Diphenyl Ether Derivatives Containing a Five-Membered Heterocycle

Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is an important target for discovering novel herbicides, and it causes bleaching symptoms by inhibiting the synthesis of chlorophyll and heme. In this study, the active fragments of several commercial herbicides were joined by substructure splicing and bioisosterism, and a series of novel diphenyl ether derivatives containing five-membered heterocycles were synthesized. The greenhouse herbicidal activity and the PPO inhibitory activity in vitro were discussed in detail. The results showed that most compounds had good PPO inhibitory activity, and target compounds containing trifluoromethyl groups tended to have higher activity. Among them, compound G4 showed the best inhibitory activity, with a half-maximal inhibitory concentration (IC50) of 0.0468 μmol/L, which was approximately 3 times better than that of oxyfluorfen (IC50 = 0.150 μmol/L). In addition, molecular docking indicated that compound G4 formed obvious π-πstacking interactions and hydrogen bond interactions with PHE-392 and ARG-98, respectively. Remarkably, compound G4 had good safety for corn, wheat, rice, and soybean, and the cumulative concentration in crops was lower than that of oxyfluorfen. Therefore, compound G4 can be used to develop potential lead compounds for novel PPO inhibitors.