339283-33-9Relevant articles and documents
KPF6-Mediated Esterification and Amidation of Carboxylic Acids
Sonam, None,Shinde, Vikki N.,Kumar, Anil
, p. 2651 - 2661 (2022/02/07)
A novel KPF6-promoted green method has been developed for the synthesis of esters and amides. A wide range of carboxylic acids and alcohols or amines worked well under the developed reaction conditions, thus providing good to excellent (61-98%) yields of
Catalytic asymmetric conjugate allylation of coumarins
Kuang, Yulong,Liu, Xiaohua,Chang, Lu,Wang, Min,Lin, Lili,Feng, Xiaoming
supporting information; experimental part, p. 3814 - 3817 (2011/09/15)
A catalytic asymmetric conjugate allylation was successfully developed to synthesize potential pharmacologically active 4-allyl-2-oxochroman skeletons. A dual activation strategy was employed by using N,N′-dioxide-Yb(OTf) 3 to activate coumarins and using (CuOTf)2?C 7H8 to activate tetraallyltin via transmetalation, respectively. Good yields and enantioselectivities were obtained under mild conditions.
Mild decarboxylative allylation of coumarins
Jana, Ranjan,Trivedi, Rushi,Tunge, Jon A.
supporting information; experimental part, p. 3434 - 3436 (2009/12/01)
Allyl esters of 3-carboxylcoumarins undergo facile decarboxylative coupling at just 25-50 °C. This represents the first extension of decarboxylative C-C bond-forming reactions to the coupling of aromatics with sp 3-hybridized electrophiles. Finally, the same concept can be applied to the sp2-sp3 couplings of pyrones and flavones. Thus, a variety of biologically important heteroaromatics can be readily functionalized without the need for strong bases or stoichiometric organometallics that are typically required for more standard cross-coupling reactions.