340187-12-4

Basic information

• Product Name: 2-(FMOC-AMINO)ETHYL BROMIDE
• Synonyms: (9H-Fluoren-9-yl)Methyl (2-broMoethyl)carbaMate;Fmoc-2-aminoethylbromide≥ 98% (HPLC)
• CAS NO: 340187-12-4
• Molecular Formula: C₁₇H₁₆BrNO₂
• Molecular Weight: 346.22
• Product Categories: Bifunctional Crosslinkers;Building Blocks;Chemical Biology;Chemical Synthesis;Linkers;Nitrogen Compounds;Organic Building Blocks;Peptide Chemistry;Protected Amines
• Mol File: 340187-12-4.mol

Chemical Properties

• Melting Point: 122-124 °C
• Boiling Point: 491.9°C at 760 mmHg
• Flash Point: 251.3°C
• Appearance: /
• Density: 1.416g/cm³
• Vapor Pressure: 8.07E-10mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: 2-8°C
• PKA: 11.13±0.46(Predicted)
• CAS DataBase Reference: 2-(FMOC-AMINO)ETHYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(FMOC-AMINO)ETHYL BROMIDE(340187-12-4)
• EPA Substance Registry System: 2-(FMOC-AMINO)ETHYL BROMIDE(340187-12-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 340187-12-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(FMOC-AMINO)ETHYL BROMIDE is used as a starting material for the preparation of tetrahydroisoquinoline compounds, which act as GPR119 modulators. These modulators are crucial in the treatment and prevention of GPR119-associated disorders, making Fmoc-AEEBr an essential component in the development of novel therapeutic agents.
Used in Chemical Synthesis:
In the chemical synthesis industry, 2-(FMOC-AMINO)ETHYL BROMIDE is used as a versatile reagent for the creation of a wide array of organic molecules. Its unique chemical properties allow for the formation of various functional groups and structures, making it a valuable tool in the synthesis of complex organic compounds for a multitude of applications, including pharmaceuticals, agrochemicals, and specialty chemicals.

InChI:InChI=1/C17H16BrNO2/c18-9-10-19-17(20)21-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,19,20)

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 105496-31-9 N-(9-fluorenylmethoxycarbonyl)-2-aminoethanol 

Relevant articles and documents

N-bromosuccinimide promoted synthesis of β-amino bromides under Appel reaction condition

An efficient and facile method has been developed for the synthesis of chiral β-amino bromides from their corresponding alcohols under Appel reaction conditions. This approach allows for the deoxybromination of a variety of β-amino alcohols in excellent y

Near infrared fluorescence probe with extremely acid pH response as well as preparation method and application thereof

The invention provides a near infrared fluorescence probe with extremely acid pH response. The chemical structural formula is shown by a formula (I), wherein X is -C(CH3)2-, -O-, -S- or -Se-; Z is -CH2-Ph or a group shown by -R'NH2; R' is C1-12 alkylene; R1 and R2 are separately selected from H atom, C1-18 alkyl or a group shown by -SO3R5; R5 is C1-18 alkyl or benzyl; R3 and R4 are separately selected from C1-18 alkyl or benzyl; and Y is F, Cl, Br or I. The near infrared fluorescence probe has the advantages of relatively low pKa value, relatively high sensitivity to H, high selectivity, relatively large stocks displacement, little background interference and relatively low harm to cells and living body and is very suitable for detecting pH in an extremely acid environment and overcomes the defects of the fluorescence probes of the prior art. The invention also provides a preparation method and an application of the probe.