- An improved synthesis of β-carboline and azepino-and azocino[3,4-b]indole derivatives from lactams
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The Vilsmeier formylation of butyrolactam, N-methylbutyrolactam, N-methylvalerolactam, and N-methylcaprolactam followed by treatment with aryl hydrazines afforded the 2,3,4,9-tetrahydro-1H-β-carbolin-1-ones, 3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-ones, and 2,3,4,5,6,11-hexahydro- 1H-azocino[3,4-b]indol-1-ones. The synthesis was performed as a one-pot process without isolating the intermediate a-formyl lactams.
- Tokmakov
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p. 211 - 216
(2014/06/23)
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- An improved synthesis of β-carboline and azepino- and azocino[3,4-b]indole derivatives from lactams
-
The Vilsmeier formylation of butyrolactam, N-methylbutyrolactam, N-methylvalerolactam, and N-methylcaprolactam followed by treatment with aryl hydrazines afforded the 2,3,4,9-tetrahydro-1H-β-carbolin-1-ones,3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-ones, and 2,3,4,5,6,11-hexahydro-1H-azocino[3,4-b]indol-1-ones. The synthesis was performed as a one-pot process without isolating the intermediate α-formyl lactams.
- Tokmakov
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p. 211 - 216
(2015/09/28)
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- REACTION OF ARYLHYDRAZINES WITH α-FORMYLBUTYROLACTAM DERIVATIVES
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The Vilsmeier formylation of butyrolactam and N-phenylbutyrolactam has given their α-dimethylaminomethylene derivatives.The reaction of the latter with α-substituted arylhydrazines leads to the formation of 1-oxo-1,2,3,4-tetrahydro-β-carbolines.When unsub
- Tokmakov, G. P.,Zemyanova. T. G.,Grandberg, I. I.
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