Preparation method of 7-piperazinyl benzothiophene or salt thereof
The invention discloses a preparation method of 7-piperazinyl benzothiophene or salt thereof, comprising the following steps: (1) carrying out substitution ring closing reaction on a compound 3 and acompound 4 to obtain a compound 5; (2) carrying out hydr
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Paragraph 0059-0062
(2020/05/14)
Method for preparing benzothiophene derivative
The invention relates to a method for preparing a benzothiophene derivative. The method comprises the following steps: taking 7-nitrothiophene as a raw material, and forming a thiophene derivative through nucleophilic substitution. The method provided by the invention has the advantages of mild reaction conditions, simple operation, controllable post-treatment and convenient quality control, and is beneficial to large-scale industrial production.
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Paragraph 0082-0086
(2020/05/14)
ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I' PATHWAY AND METHODS OF USE THEREOF
The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.
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Page/Page column 62
(2020/03/05)
ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I" PATHWAY AND METHODS OF USE THEREOF
The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.
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Paragraph 0460
(2020/03/01)
Discovery and optimization of p38 inhibitors via computer-assisted drug design
Integration of computational methods, X-ray crystallography, and structure-activity relationships will be disclosed, which lead to a new class of p38 inhibitors that bind to p38 MAP kinase in a Phe out conformation.
Goldberg, Daniel R.,Hao, Ming-Hong,Qian, Kevin C.,Swinamer, Alan D.,Gao, Donghong A.,Xiong, Zhaoming,Sarko, Chris,Berry, Angela,Lord, John,Magolda, Ronald L.,Fadra, Tazmeen,Kroe, Rachel R.,Kukulka, Alison,Madwed, Jeffrey B.,Martin, Leslie,Pargellis, Christopher,Skow, Donna,Song, Jinhua J.,Tan, Zhulin,Torcellini, Carol A.,Zimmitti, Clare S.,Yee, Nathan K.,Moss, Neil
p. 4016 - 4026
(2008/02/12)
Compounds useful in treating cytokine mediated diseases
Disclosed are amide compounds of formula(I): wherein Ar1, Q, Y and R3-R6 of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating d
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Page 24
(2008/06/13)
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