Abstract: The ranges of variation of the rate constant (0.031– 0.153L·mol–1·s–1), energyof activation (21– 55 kJ/mol), and entropy of activation (88–191J·mol–1·K–1) for thereaction of benzamide with 3-nitrobenzenesulfonyl chloride in aqueous1,4-dioxane with a concentration of water of 15–40 wt % have been determined bystudying the reaction kinetics in the temperature range 298–313 K. The potentialenergy surface for the gas-phase reaction of benzamide with3-nitrobenzenesulfonyl chloride has been simulated at the DFT B3LYP/6-311G(d,p) level of theory; the results of quantum chemical simulationsuggest bimolecular nucleophilic substitution mechanism of this reaction.
Kustova,Kochetova,Kruglyakova
p. 1098 - 1102
(2021/09/08)
Catalytic activity of magnetic Fe3O4@Diatomite earth and acetic acid for the N-acylation of sulfonamides
The Br?nsted and Lewis acidic promoted N-acylation of sulfonamides with acetic anhydride or benzoyl chloride has been achieved using glacial acetic acid and magnetic Fe3O4@Diatomite earth. Use of acetic acid as solvent omits the need for organic bases and permits the isolation of products by filtration and precipitation. Additionally, the magnetic composite Fe3O4@Diatomite acts as a conjugate proton super acid, enabling the acylation of sulfonamide compounds.
Ghasemi, Mohammad Hadi,Kowsari, Elaheh,Hosseini, Seyed Kiumars
supporting information
p. 387 - 391
(2016/01/12)
An expeditious and convenient synthesis of acylsulfonamides utilizing polymer-supported reagents
Acylsulfonamides can be rapidly and conveniently synthesized from a variety of carboxylic acids and sulfonamides utilizing the commercially available reagents, PS-DCC and DMAP under mild reaction conditions. DMAP can be efficiently scavenged by utilizatio
Wang, Ying,Sarris, Kathy,Sauer, Daryl R.,Djuric, Stevan W.
p. 5181 - 5184
(2008/02/08)
Benzodiazepine derivatives, compositions containing them and their use in therapy
Compounds of formula (I), and salts and prodrugs thereof wherein: R1 represents optionally substituted C? ??alkyl or C???cycloalkyl; R2 represents an optionally substituted phenyl or pyridyl group; R3 represents C??? alkyl or halo; R? represents C??? cycloalkyl; X is 0, 1, 2 or 3; are CCK and/or gastrin antagonists. They and compositions thereof are therefore useful in therapy.
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(2008/06/13)
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