3409-79-8

Upstream product

• 55-21-0 benzamide 
• 121-51-7 3-nitrobenzenesulphonyl chloride 
• 121-52-8 3-nitrophenylsulfonamide 
• 65-85-0 benzoic acid 
• 89463-99-0 N-(3-nitro-benzenesulfonyl)-sulfur imide oxide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 4380-74-9 1-(phenylcarbonylaminosulphonyl)-3-aminobenzene 

Relevant academic research and scientific papers

Reactivity of Benzamide toward Sulfonylation

Abstract: The ranges of variation of the rate constant (0.031– 0.153L·mol–1·s–1), energyof activation (21– 55 kJ/mol), and entropy of activation (88–191J·mol–1·K–1) for thereaction of benzamide with 3-nitrobenzenesulfonyl chloride in aqueous1,4-dioxane with a concentration of water of 15–40 wt % have been determined bystudying the reaction kinetics in the temperature range 298–313 K. The potentialenergy surface for the gas-phase reaction of benzamide with3-nitrobenzenesulfonyl chloride has been simulated at the DFT B3LYP/6-311G(d,p) level of theory; the results of quantum chemical simulationsuggest bimolecular nucleophilic substitution mechanism of this reaction.

Catalytic activity of magnetic Fe3O4@Diatomite earth and acetic acid for the N-acylation of sulfonamides

The Br?nsted and Lewis acidic promoted N-acylation of sulfonamides with acetic anhydride or benzoyl chloride has been achieved using glacial acetic acid and magnetic Fe3O4@Diatomite earth. Use of acetic acid as solvent omits the need for organic bases and permits the isolation of products by filtration and precipitation. Additionally, the magnetic composite Fe3O4@Diatomite acts as a conjugate proton super acid, enabling the acylation of sulfonamide compounds.

An expeditious and convenient synthesis of acylsulfonamides utilizing polymer-supported reagents

Acylsulfonamides can be rapidly and conveniently synthesized from a variety of carboxylic acids and sulfonamides utilizing the commercially available reagents, PS-DCC and DMAP under mild reaction conditions. DMAP can be efficiently scavenged by utilizatio

Benzodiazepine derivatives, compositions containing them and their use in therapy

Compounds of formula (I), and salts and prodrugs thereof wherein: R1 represents optionally substituted C? ??alkyl or C???cycloalkyl; R2 represents an optionally substituted phenyl or pyridyl group; R3 represents C??? alkyl or halo; R? represents C??? cycloalkyl; X is 0, 1, 2 or 3; are CCK and/or gastrin antagonists. They and compositions thereof are therefore useful in therapy.