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342045-65-2

ethyl 2-(1,3-benzodioxol-5-yl)-4-hydroxy-7-methoxy-3-quinolinecarboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 342045-65-2 Structure

  • Basic information

    1. Product Name: ethyl 2-(1,3-benzodioxol-5-yl)-4-hydroxy-7-methoxy-3-quinolinecarboxylate
    2. Synonyms: ethyl 2-(1,3-benzodioxol-5-yl)-4-hydroxy-7-methoxy-3-quinolinecarboxylate
    3. CAS NO:342045-65-2
    4. Molecular Formula: C20H17NO6
    5. Molecular Weight: 367.35208
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 342045-65-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ethyl 2-(1,3-benzodioxol-5-yl)-4-hydroxy-7-methoxy-3-quinolinecarboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: ethyl 2-(1,3-benzodioxol-5-yl)-4-hydroxy-7-methoxy-3-quinolinecarboxylate(342045-65-2)
    11. EPA Substance Registry System: ethyl 2-(1,3-benzodioxol-5-yl)-4-hydroxy-7-methoxy-3-quinolinecarboxylate(342045-65-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 342045-65-2(Hazardous Substances Data)

342045-65-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 342045-65-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,2,0,4 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 342045-65:
(8*3)+(7*4)+(6*2)+(5*0)+(4*4)+(3*5)+(2*6)+(1*5)=112
112 % 10 = 2
So 342045-65-2 is a valid CAS Registry Number.

342045-65-2Downstream Products

342045-65-2Relevant articles and documents

Lead optimization of 3-carboxyl-4(1 H)-quinolones to deliver orally bioavailable antimalarials

Zhang, Yiqun,Clark, Julie A.,Connelly, Michele C.,Zhu, Fangyi,Min, Jaeki,Guiguemde, W. Armand,Pradhan, Anupam,Iyer, Lalitha,Furimsky, Anna,Gow, Jason,Parman, Toufan,El Mazouni, Farah,Phillips, Margaret A.,Kyle, Dennis E.,Mirsalis, Jon,Guy, R. Kiplin

supporting information; experimental part, p. 4205 - 4219 (2012/07/02)

Malaria is a protozoal parasitic disease that is widespread in tropical and subtropical regions of Africa, Asia, and the Americas and causes more than 800,000 deaths per year. The continuing emergence of multidrug-resistant Plasmodium falciparum drives the ongoing need for the development of new and effective antimalarial drugs. Our previous work has explored the preliminary structural optimization of 4(1H)-quinolone ester derivatives, a new series of antimalarials related to the endochins. Herein, we report the lead optimization of 4(1H)-quinolones with a focus on improving both antimalarial potency and bioavailability. These studies led to the development of orally efficacious antimalarials including quinolone analogue 20g, a promising candidate for further optimization.

Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones

Zhang, Yiqun,Guiguemde, W. Armand,Sigal, Martina,Zhu, Fangyi,Connelly, Michele C.,Nwaka, Solomon,Guy, R. Kiplin

experimental part, p. 2756 - 2766 (2010/06/19)

Malaria is endemic in tropical and subtropical regions of Africa, Asia, and the Americas. The increasing prevalence of multi-drug-resistant Plasmodium falciparum drives the ongoing need for the development of new antimalarial drugs. In this light, novel s

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