342045-65-2

Basic information

• Product Name: ethyl 2-(1,3-benzodioxol-5-yl)-4-hydroxy-7-methoxy-3-quinolinecarboxylate
• Synonyms: ethyl 2-(1,3-benzodioxol-5-yl)-4-hydroxy-7-methoxy-3-quinolinecarboxylate
• CAS NO: 342045-65-2
• Molecular Formula: C20H17NO6
• Molecular Weight: 367.35208
• Mol File: 342045-65-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-(1,3-benzodioxol-5-yl)-4-hydroxy-7-methoxy-3-quinolinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(1,3-benzodioxol-5-yl)-4-hydroxy-7-methoxy-3-quinolinecarboxylate(342045-65-2)
• EPA Substance Registry System: ethyl 2-(1,3-benzodioxol-5-yl)-4-hydroxy-7-methoxy-3-quinolinecarboxylate(342045-65-2)

Safety Data

• Hazardous Substances Data: 342045-65-2(Hazardous Substances Data)

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 56881-19-7 Diethyl 2-<(3-methoxyphenylamino)methylene>malonate 
• 1226760-44-6 C₂₀H₁₆ClNO₅ 
• 536-90-3 m-Anisidine 
• 71083-05-1 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 77156-85-5 Ethyl 4-chloro-7-methoxyquinoline-3-carboxylate 
• 1226760-36-6 ethyl 2-bromo-4-chloro-7-methoxyquinoline-3-carboxylate 
• 1226760-29-7 C₁₃H₁₂ClNO₄ 

Relevant articles and documents

Lead optimization of 3-carboxyl-4(1 H)-quinolones to deliver orally bioavailable antimalarials

Malaria is a protozoal parasitic disease that is widespread in tropical and subtropical regions of Africa, Asia, and the Americas and causes more than 800,000 deaths per year. The continuing emergence of multidrug-resistant Plasmodium falciparum drives the ongoing need for the development of new and effective antimalarial drugs. Our previous work has explored the preliminary structural optimization of 4(1H)-quinolone ester derivatives, a new series of antimalarials related to the endochins. Herein, we report the lead optimization of 4(1H)-quinolones with a focus on improving both antimalarial potency and bioavailability. These studies led to the development of orally efficacious antimalarials including quinolone analogue 20g, a promising candidate for further optimization.

Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones

Malaria is endemic in tropical and subtropical regions of Africa, Asia, and the Americas. The increasing prevalence of multi-drug-resistant Plasmodium falciparum drives the ongoing need for the development of new antimalarial drugs. In this light, novel s