34206-49-0

Basic information

• Product Name: 5-BROMO-2,3-DIHYDROXYPYRIDINE
• Synonyms: 5-BROMO-2,3-PYRIDINEDIOL;5-BROMO-2,3-DIHYDROXYPYRIDINE;2,3-DIHYDROXY-5-BROMOPYRIDINE;5-BROMO-2,3-PYRIDINEDIOL (5-BROMO-2,3-DIHYDROXYPYRIDINE);5-Bromo-3-hydroxy-1H-pyridin-2-one;5-broMopyridine-2,3-diol;5-Bromo-3-hydroxypyridin-2(1H)-one;5-Bromo-3-hydroxy-2(1H)-pyridinone
• CAS NO: 34206-49-0
• Molecular Formula: C₅H₄BrNO₂
• Molecular Weight: 189.99
• EINECS: -0
• Product Categories: Pyridine;API intermediates;Bromopyridines;Halopyridines
• Mol File: 34206-49-0.mol

Chemical Properties

• Melting Point: 249 °C
• Boiling Point: 487.112 °C at 760 mmHg
• Flash Point: 248.397 °C
• Appearance: /
• Density: 2.044
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.671
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.16±0.58(Predicted)
• CAS DataBase Reference: 5-BROMO-2,3-DIHYDROXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2,3-DIHYDROXYPYRIDINE(34206-49-0)
• EPA Substance Registry System: 5-BROMO-2,3-DIHYDROXYPYRIDINE(34206-49-0)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-36
• Hazardous Substances Data: 34206-49-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Bromo-2,3-dihydroxypyridine is used as a building block for the synthesis of pharmaceutical compounds, leveraging its unique structure to create new drugs with potential therapeutic benefits.
Used in Agrochemical Production:
In the agrochemical industry, 5-Bromo-2,3-dihydroxypyridine is utilized as a key intermediate in the development of new agrochemicals, contributing to the creation of effective products for agricultural applications.
Used in Neurological Disorder Treatment:
5-Bromo-2,3-dihydroxypyridine is studied for its potential use in treating neurological disorders, owing to its biological activity that may offer therapeutic advantages in managing such conditions.
Used as an Antioxidant:
5-BROMO-2,3-DIHYDROXYPYRIDINE is recognized for its antioxidant properties, making it a candidate for use in applications where protection against oxidative stress is required, potentially benefiting health and longevity.
Used in Organic Synthesis:
5-Bromo-2,3-dihydroxypyridine is employed as a versatile intermediate in organic synthesis, enabling the production of a wide range of functional molecules for various industries and applications.

InChI:InChI=1/C5H4BrNO2/c6-3-1-4(8)5(9)7-2-3/h1-2,8H,(H,7,9)

Upstream product

• 98-01-1 furfural 

Downstream Products

• 1431637-92-1 3-(methoxymethoxy)-5-(2-phenylethyl)pyridin-2(1H)-one 
• 1417710-21-4 3-hydroxy-5-(2-phenylethyl)pyridin-2(1H)-one 
• 1333146-86-3 3-benzyloxy-5-bromo-1-methyl-1H-pyridin-2-one 
• 1333146-67-0 3-hydroxy-1-methyl-5-(4-phenylpyrimidin-2-yl)pyridin-2(1H)-one 
• 1333147-16-2 3-(benzyloxy)-1-methyl-5-(4-phenylpyrimidin-2-yl)pyridin-2(1H)-one 
• 1333146-64-7 3-hydroxy-1-methyl-5-(4-phenyl-1H-imidazol-1-yl)pyridin-2(1H)-one 
• 1333147-10-6 3-(benzyloxy)-1-methyl-5-(4-phenyl-1H-imidazol-1-yl)pyridin-2(1H)-one 
• 1333146-61-4 3-hydroxy-1-methyl-5-(3-phenyl-1H-pyrazol-1-yl)pyridin-2(1H)-one 
• 1333147-09-3 3-(benzyloxy)-1-methyl-5-(3-phenyl-1H-pyrazol-1-yl)pyridin-2(1H)-one 
• 1333146-58-9 3-hydroxy-1-methyl-5-(2-oxo-4-phenylpyrrolidin-1-yl)pyridin-2(1H)-one 
• 1333147-08-2 3-(benzyloxy)-1-methyl-5-(2-oxo-4-phenylpyrrolidin-1-yl)pyridin-2(1H)-one 
• 1333146-53-4 5-biphenyl-3-yl-3-hydroxy-1-methylpyridin-2(1H)-one 
• 1333146-97-6 3-(benzyloxy)-5-(biphenyl-3-yl)-1-methylpyridin-2(1H)-one 
• 1333146-49-8 5-[4-chloro-3-(trifluoromethyl)phenyl]-3-hydroxy-1-(propan-2-yl)pyridin-2(1H)-one 

Relevant articles and documents

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Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain.

A number of novel guanine derivatives containing heterocyclic moieties at the O6-position have been synthesized using a purine quaternary salt which reacts with alkoxides under mild conditions. Initially O6-substituents were investigated in which the benzene ring of the known agent, O6-benzylguanine, was replaced by unsubstituted heterocyclic rings. The ability of these agents to inactivate the DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase), both as pure recombinant protein and in the human lymphoblastoid cell line Raji, has been compared with that of O6-benzylguanine. The present paper focuses on O6-substituents with basic rings, and under standard conditions several of them proved more effective than benzyl for inactivation of both recombinant and Raji ATase. Among the pyridine derivatives, the 2-picolyl compound 7 is not very active in contrast to the 3- and 4-picolyl compounds, and this influenced our choice of isomers of other basic ring systems for study. Since halogen substitution in the thiophene ring considerably increased the activity (17 versus 6), similar modifications in the pyridine series were examined. The more polar O6-substituents in this study are on the whole compatible with the stereochemical requirements of the ATase protein, and their pharmacological properties may be valuable in subsequent in vivo investigations, particularly the thenyl (6), 5-thiazolylmethyl (12), 5-bromothenyl (17), and 2-chloro-4-picolyl (21) derivatives.