1333146-86-3

Usage

Uses

Used in Organic Synthesis:
3-Benzyloxy-5-bromo-1-methyl-1H-pyridin-2-one is used as a building block in organic synthesis for the creation of new chemical entities with diverse biological activities. Its functional groups enable further modification and derivatization, making it a valuable component in the development of novel compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-Benzyloxy-5-bromo-1-methyl-1H-pyridin-2-one is used as a starting material for the development of new drugs and biologically active compounds. Its potential biological and pharmacological activities make it a promising candidate for various therapeutic applications, including the treatment of diseases and disorders.

Upstream product

• 34206-49-0 5-bromo-2,3-dihydroxy-pyridine 
• 34206-49-0 5-bromo-3-hydroxypyridin-2(1H)-one 
• 1333146-84-1 3-benzyloxy-5-bromo-1,2-dihydropyridin-2-ol 
• 74-88-4 methyl iodide 
• 100-39-0 benzyl bromide 

Downstream Products

• 1333147-10-6 3-(benzyloxy)-1-methyl-5-(4-phenyl-1H-imidazol-1-yl)pyridin-2(1H)-one 
• 1333147-09-3 3-(benzyloxy)-1-methyl-5-(3-phenyl-1H-pyrazol-1-yl)pyridin-2(1H)-one 
• 1333146-46-5 5-(2,4-dichloro-phenyl)-3-hydroxy-1-methyl-1H-pyridin-2-one 
• 1333146-53-4 5-biphenyl-3-yl-3-hydroxy-1-methylpyridin-2(1H)-one 
• 1333146-58-9 3-hydroxy-1-methyl-5-(2-oxo-4-phenylpyrrolidin-1-yl)pyridin-2(1H)-one 
• 1333146-61-4 3-hydroxy-1-methyl-5-(3-phenyl-1H-pyrazol-1-yl)pyridin-2(1H)-one 
• 1333147-14-0 [5-(benzyloxy)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl]boronic acid 
• 1333147-16-2 3-(benzyloxy)-1-methyl-5-(4-phenylpyrimidin-2-yl)pyridin-2(1H)-one 
• 1333146-67-0 3-hydroxy-1-methyl-5-(4-phenylpyrimidin-2-yl)pyridin-2(1H)-one 
• 1333146-64-7 3-hydroxy-1-methyl-5-(4-phenyl-1H-imidazol-1-yl)pyridin-2(1H)-one 

Relevant academic research and scientific papers

New Pyridinones and Isoquinolinones as Inhibitors of the Bromodomain BRD9

The present invention encompasses compounds of general formula (I) wherein the groups R1 to R9, X1 and X2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, e.g. cancer, pharmaceutical preparations containing such compounds and their uses as a medicament.

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF

Catechol-based inhibitors of ERCC1-XPF endonuclease activity were identified from a high-throughput screen. Exploration of the structure-activity relationships within this series yielded compound 13, which displayed an ERCC1-XPF IC50 of 0.6 μM, high selectivity against FEN-1 and DNase I and activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays in A375 melanoma cells. Screening of fragments as potential alternatives to the catechol group revealed that 3-hydroxypyridones are able to inhibit ERCC1-XPF with high ligand efficiency, and elaboration of the hit gave compounds 36 and 37 which showed promising ERCC1-XPF IC50 values of 10 μM.

INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS

The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. Th