343374-44-7

Basic information

• Product Name: [5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL
• Synonyms: [5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL;5-(2-CHLOROPHENYL)-3-ISOXAZOLEMETHANOL;5-(2-Chlorophenyl)-3-hydroxymethylisoxazole, 97%
• CAS NO: 343374-44-7
• Molecular Formula: C₁₀H₈ClNO₂
• Molecular Weight: 209.63
• Mol File: 343374-44-7.mol

Chemical Properties

• Boiling Point: 370.5±32.0 °C(Predicted)
• Appearance: /
• Density: 1.339±0.06 g/cm3(Predicted)
• PKA: 12.96±0.10(Predicted)
• CAS DataBase Reference: [5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL(343374-44-7)
• EPA Substance Registry System: [5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL(343374-44-7)

Safety Data

• Hazardous Substances Data: 343374-44-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL is used as a pharmaceutical compound for its potential to exhibit various biological activities. [5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL is being studied for its possible antibacterial, antifungal, and antiviral properties, which could make it a valuable asset in the development of new medications to combat these types of infections.
Additionally, [5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL is being investigated for its potential anti-inflammatory and anticancer activities. If proven effective, [5-(2-CHLOROPHENYL)-3-ISOXAZOLYL]METHANOL could be utilized in the development of treatments for inflammatory conditions and cancer, offering new therapeutic options for patients.
The specific properties and potential applications of [5-(2-chlorophenyl)-3-isoxazolyl]methanol may require further research and characterization to fully understand its capabilities and potential impact on the pharmaceutical industry.

Upstream product

• 338982-35-7 4-(2-chloro-phenyl)-2,4-dioxo-butyric acid ethyl ester 

Downstream Products

• 1378938-15-8 2-amino-3-cyano-7-dimethylamino-4-(5-(2-chlorophenyl)-isoxazol-3-yl)-4H-chromene 
• 339019-69-1 3-chloromethyl-5-(2-chloro-phenyl)-isoxazole 

Relevant articles and documents

Design, synthesis and biological evaluation of stilbene derivatives as novel inhibitors of protein tyrosine phosphatase 1B

By imitating the scaffold of lithocholic acid (LCA), a natural steroidal compound displaying Protein Tyrosine Phosphatase 1B (PTP1B) inhibitory activity, a series of stilbene derivatives containing phenyl-substituted isoxazoles were designed and synthesized. The structures of the title compounds were confirmed by 1H-NMR, 13C-NMR and HRMS. Activities of the title compounds were evaluated on PTP1B and the homologous enzyme TCPTP by using a colorimetric assay. Most of the target compounds had good activities against PTP1B. Among them, compound 29 (IC50 = 0.91 ± 0.33 μM), characterized by a 5-(2,3-dichlorophenyl) isoxazole moiety, exhibited an activity about 14-fold higher than the lead compound LCA and a 4.2-fold selectivity over TCPTP. Compound 29 was identified as a competitive inhibitor of PTP1B with a Ki value of 0.78 μM in enzyme kinetic studies.

2-Amino-3-cyano-4-(5-arylisoxazol-3-yl)-4H-chromenes: Synthesis and in vitro cytotoxic activity

A new series of 4-aryl-4H-chromenes bearing a 5-arylisoxazol-3-yl moiety at the C-4 position were prepared as potential anticancer agents. The in vitro cytotoxic activity of the synthesized compounds was investigated against a panel of tumor cell lines in