344-38-7

Basic information

• Product Name: 5-Bromo-2-nitrobenzotrifluoride
• Synonyms: TIMTEC-BB SBB009973;LABOTEST-BB LT01143393;4-BROMO-1-NITRO-2-(TRIFLUOROMETHYL)BENZENE;5-BROMO-2-NITROBENZOTRIFLUORIDE;5-BROMO-2-NITRO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE;5-BROMO-A-A,A-TRIFLUORO-2-NITROTOLUENE;2-NITRO-5-BROMOBENZOTRIFLUORIDE;5-Bromo-2-nitrobenzotrifluoride, 97+%
• CAS NO: 344-38-7
• Molecular Formula: C₇H₃BrF₃NO₂
• Molecular Weight: 270
• EINECS: -0
• Product Categories: Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 344-38-7.mol

Chemical Properties

• Melting Point: 33-35 °C(lit.)
• Boiling Point: 95-100 °C5 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear yellow/Liquid
• Density: 1,799 g/cm3
• Vapor Pressure: 0.0395mmHg at 25°C
• Refractive Index: 1.522-1.524
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• BRN: 2650701
• CAS DataBase Reference: 5-Bromo-2-nitrobenzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-nitrobenzotrifluoride(344-38-7)
• EPA Substance Registry System: 5-Bromo-2-nitrobenzotrifluoride(344-38-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26-37/39-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 344-38-7(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow liquid

InChI:InChI=1/C7H3BrF3NO2/c8-4-1-2-6(12(13)14)5(3-4)7(9,10)11/h1-3H

Upstream product

• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 98-16-8 3-trifluoromethylaniline 
• 320-38-7 4-nitro-3-(trifluoromethyl)benzoic acid 
• 98-08-8 α,α,α-trifluorotoluene 
• 393-11-3 4-nitro-3-(trifluoromethyl)benzeneamine 
• 106-95-6 allyl bromide 

Downstream Products

• 445-02-3 4-bromo-2-trifluoromethyl-aniline 
• 644-08-6 4-Methylbiphenyl 
• 344-41-2 4-nitro-3-(trifluoromethyl)-1,1’-biphenyl 
• 117367-10-9 N-(4-nitro-3-(trifluoromethyl)phenyl)benzamide 
• 13311-84-7 Flutamide 
• 1618656-65-7 5-(4-nitro-3-(trifluoromethyl)phenyl)-6-phenylimidazo[2,1-b]thiazole 
• 1618656-81-7 3-methyl-2,5-bis(3-nitrophenyl)-6-phenylimidazo[2,1-b]thiazole 
• 1618656-80-6 3-methyl-5-(4-nitro-3-(trifluoromethyl)phenyl)-6-phenylimidazo[2,1-b]thiazole 
• 1618656-77-1 3-(4-nitro-3-(trifluoromethyl)phenyl)-2-phenyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole 
• 1618656-71-5 3-(4-nitro-3-(trifluoromethyl)phenyl)-2-phenylbenzo[d]imidazo[2,1-b]thiazole 
• 1610696-32-6 4-nitro-3-(trifluoromethyl)-N-(4-[[tris(propan-2-yl)silyl]oxy]phenyl)aniline 
• 1596345-29-7 5-(3-(trifluoromethyl)-4-nitrophenyl)-1,3-diphenyl-1H-pyrazole-4-carbaldehyde 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF ORGANIC HALIDES

The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.

PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES

The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.

Para-Selective Halogenation of Nitrosoarenes with Copper(II) Halides

The para-selective direct bromination and chlorination of nitrosoarenes with copper(II) bromide and chloride is reported. Under mild reaction conditions, a range of halogenated arylnitroso compounds are obtained in moderate to good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of a one-pot procedure to obtain the corresponding para-halogenated aniline- and nitrobenzene derivatives.

Aromatic allylation via diazotization: Metal-free C-C bond formation

A new method for the synthesis of allyl aromatic compounds not involving any metal-containing reagent or catalyst has been developed. Arylamines substituted with a large number of different substituents were converted via diazotizative deamination with tert-butyl nitrite in allyl bromide and acetonitrile to the corresponding allyl aromatic compounds. The allylation reaction was found to be suitable for larger scale synthesis due to short reaction times, a nonextractive workup, and robustness toward moisture, air, and type of solvent.