344294-32-2Relevant articles and documents
Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity
Bernstein, Peter R.,Dang, Xiawei,Devanathan, Sriram,Dorn, Gerald W.,Franco, Antonietta,Fu, Lijun,Walters, Daniel,Williams, Sidney B.
, p. 12506 - 12524 (2021/09/11)
Mitochondrial fragmentation from defective fusion or unopposed fission contributes to many neurodegenerative diseases. Small molecule mitofusin activators reverse mitochondrial fragmentation in vitro, promising a novel therapeutic approach. The first-in-c
Oxidative Cyclization of δ,ε- and ε,ζ-Unsaturated Enol Silyl Ethers and Unsaturated Siloxycyclopropanes
Snider, Barry B.,Kwon, Taesoo
, p. 2399 - 2410 (2007/10/02)
Oxidative cyclization of δ,ε- and ε,ζ-unsaturated enol silyl ethers 4a and 4b with cupric triflate and cuprous oxide or ceric ammonium nitrate and sodium bicarbonate in acetonitrile provides the tricyclic ketones 5a and 5b stereoselectively.These cyclizat
NEW CHEMISTRY OF ZWITTERIONIC PEROXIDES ARISING BY PHOTOOXYGENATION OF ENOL ETHERS
Jefford, Charles W.,Boukouvalas, John,Kohmoto, Shigeo,Bernardinelli, Gerald
, p. 2081 - 2088 (2007/10/02)
The rose bengal-sensitized photooxygenation of 2-methoxynorborn-2-ene (1) in acetaldehyde gave cis-1-carboxaldehyde-3-carbomethoxycyclopentane (31percent) and the cis and trans-Me derivatives of the cis-fused exo-1,2,4-trioxanes arising by addition of a molecule of oxygen and acetaldehyde to 1 at C3 and C2 respectively (13percent).Similar photooxygenation of 2-(methoxymetylidene)adamantane in the presence of acetaldehyde, propionaldehyde and pivalaldehyde gave adamantanone (31-42percent), and the cis and trans tricyclo3.7>decane-2-spiro-6'- in yields of 32-53percent.Trioxane formation under similar conditions was experienced for 1,1-di-t-butyl-2-methoxyethene and 2-(methylmercaptomethylidene)adamantane.The results are discussed in terms of an intermediate zwitterionic peroxide which can either close directly to a 1,2-dioxetane or, if aldehyde is present, condense across the CO function giving the 1,2,4-trioxane.