344305-20-0Relevant articles and documents
Novel benzothiophene H1-antihistamines for the treatment of insomnia
Moree, Wilna J.,Jovic, Florence,Coon, Timothy,Yu, Jinghua,Li, Bin-Feng,Tucci, Fabio C.,Marinkovic, Dragan,Gross, Raymond S.,Malany, Siobhan,Bradbury, Margaret J.,Hernandez, Lisa M.,O'Brien, Zhihong,Wen, Jianyun,Wang, Hua,Hoare, Samuel R.J.,Petroski, Robert E.,Sacaan, Aida,Madan, Ajay,Crowe, Paul D.,Beaton, Graham
scheme or table, p. 2316 - 2320 (2010/09/05)
SAR of lead benzothiophene H1-antihistamine 2 was explored to identify backup candidates with suitable pharmacokinetic profiles for an insomnia program. Several potent and selective H1-antihistamines with a range of projected half-li
Sleep inducing compounds and methods relating thereto
-
Page/Page column 30, (2010/02/15)
Compounds having the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts, esters and solvates thereof, wherein R1, R2, R3a, R3b, L1, L2 and n are as defined herein. Such compounds generally function as H1 receptor ligands, and thus have utility as sleep inducing agents. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
Photochemical Cycloadditions of 2,3-Dihalobenzothiophenes: Stereochemical and Mechanistic Results
Neckers, D. C.,Wagenaar, F. L.,Hauenstein, D.,Jacobson, R. A.
, p. 1725 - 1732 (2007/10/02)
Synthetic approaches to 2-thia-3,4-benzobicyclo-1,3,6-heptatriene and to 2-thia-3,4-benzobicyclo-1,3-heptadiene requiered halogenated cyclobutanes derived from ?2s + ?2s> photocycloadditions of 2,
