344359-60-0 Usage
Chemical compound
3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenol
Contains
Pyrrolopyrimidine ring and phenol group
Inhibitor of
Cyclin-Dependent Kinase 7 (CDK7)
Role of CDK7
Regulation of cell cycle progression and transcription
Anti-cancer activity
Shown promising results in preclinical studies
Potential as
Therapeutic agent for cancer treatment
Other applications
Studying the role of CDK7 in various biological processes
Unique features
Chemical structure and inhibitory properties make it an intriguing molecule for further investigation and potential drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 344359-60-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,4,3,5 and 9 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 344359-60:
(8*3)+(7*4)+(6*4)+(5*3)+(4*5)+(3*9)+(2*6)+(1*0)=150
150 % 10 = 0
So 344359-60-0 is a valid CAS Registry Number.
344359-60-0Relevant articles and documents
7-alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines - Potent inhibitors of the tyrosine kinase c-Src
Widler, Leo,Green, Jonathan,Missbach, Martin,Susa, Mira,Altmann, Eva
, p. 849 - 852 (2007/10/03)
7-Substituted-5-aryl-pyrrolo[2,3-d]pyrimidines have been prepared starting from α-bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60c-Src with good specificity towards other tyrosine kinases (EGF-R, v-Abl).