The present invention relates to an improved process for the synthesis of lofexidine, or a pharmaceutically acceptable salt thereof, using an aluminium alkoxide as Lewis acid.
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Page/Page column 15
(2021/10/22)
A scalable, enantioselective synthesis of the r2-adrenergic agonist, lofexidine
A scalable and high-yielding synthetic route toward pure enantiomers of the α2-adrenergic agonist, lofexidine hydrochloride, is presented. Salient features include a rapid one-pot amide alkylation-imidazoline formation sequence on the carboxami
Vartak, Ashish P.,Crooks, Peter A.
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p. 415 - 419
(2010/04/22)
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