344443-16-9

Basic information

• Product Name: N-(2-Aminoethyl)-2-(2,6-dichlorophenoxy)propanamide
• Synonyms: PropanaMide, N-(2-aMinoethyl)- 2-(2,6-dichlorophenoxy)-;N-(2-Aminoethyl)-2-(2,6-dichlorophenoxy)propanamide
• CAS NO: 344443-16-9
• Molecular Formula: C11H14Cl2N2O2
• Molecular Weight: 277.14706
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Amines
• Mol File: 344443-16-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 471.1 °C at 760 mmHg
• Flash Point: 238.7 °C
• Appearance: /
• Density: 1.299 g/cm³
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate
• PKA: 14.12±0.46(Predicted)
• CAS DataBase Reference: N-(2-Aminoethyl)-2-(2,6-dichlorophenoxy)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Aminoethyl)-2-(2,6-dichlorophenoxy)propanamide(344443-16-9)
• EPA Substance Registry System: N-(2-Aminoethyl)-2-(2,6-dichlorophenoxy)propanamide(344443-16-9)

Safety Data

• Hazardous Substances Data: 344443-16-9(Hazardous Substances Data)

Usage

Chemical Properties

Dark-Red Oil

Uses

Lofexidine intermediate.

Upstream product

• 344559-34-8 (±)ethyl 2-(2,6-dichlorophenoxy)propionate 
• 107-15-3 ethylenediamine 
• 87-65-0 2,6-Dichlorophenol 
• 1112401-07-6 C₁₀H₁₀Cl₂O₃ 

Relevant articles and documents

PROCESS FOR THE SYNTHESIS OF LOFEXIDINE

The present invention relates to an improved process for the synthesis of lofexidine, or a pharmaceutically acceptable salt thereof, using an aluminium alkoxide as Lewis acid.