- TOLL-LIKE RECEPTOR 9 AGONISTS
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The present invention provides TLR9 agonists comprising, as an active ingredient, a compound represented by formula (I): (wherein a represents 0 or 1; n represents an integer of 0 to 2; m represents an integer of 0 to 5; X1 and X2 each independently represent a hydrogen atom or hydroxy; Y represents an oxygen atom or a sulfur atom; -Q1-represents -O- or the like; -Q2- represents -O- or the like; -Z- represents -O- or the like; R1, R3 and R4 each independently represent hydroxy or the like; R2 and R5 each independently represent a hydrogen atom, hydroxy or the like; and A represents 6-aminopurin-9-yl or the like) or a pharmaceutically acceptable salt thereof, and the like.
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Page/Page column 35
(2009/02/10)
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- Are glycosyl triflates intermediates in the sulfoxide glycosylation method? A chemical and 1H, 13C, and 19F NMR spectroscopic investigation
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The title question is addressed by low-temperature 1H, 13C, and 19F NMR spectroscopies in CD2CL2 as well as by the preparation of authentic samples from glycopyranosyl bromides and AgOTf. At -78°C glycosyl triflates are cleanly generated with either nonparticipating or particpating protecting groups at O-2. The glycosyl triflates identified in this manner were allowed to react with methanol, resulting in the formation of methyl glycosides. Glycosyl triflates were generated at -78°C in CD2Cl2 and allowed to warm gradually until decomposition was detected by 1H and 19F NMR spectroscopy. The decomposition temperature and products are functions of the protecting groups employed.
- Crich, David,Sun, Sanxing
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p. 11217 - 11223
(2007/10/03)
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- Peralkylation of Saccharides under Aqueous Conditions
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Treatment of saccharides with sodium hydroxide and alkyl halides in aqueous dimethyl sulfoxide solution offers a very efficient method for the complete alkylation of saccharides in high yields.
- Wang, Hui,Sun, Lihong,Glazebnik, Serge,Zhao, Kang
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p. 2953 - 2956
(2007/10/02)
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