3445-71-4

Basic information

• Product Name: 1-O,2-O,3-O,4-O,6-O-Pentamethyl-β-D-mannopyranose
• CAS NO: 3445-71-4
• Molecular Formula: C₁₁H₂₂O₆
• Molecular Weight: 250.28878
• Mol File: 3445-71-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-O,2-O,3-O,4-O,6-O-Pentamethyl-β-D-mannopyranose(CAS DataBase Reference)
• NIST Chemistry Reference: 1-O,2-O,3-O,4-O,6-O-Pentamethyl-β-D-mannopyranose(3445-71-4)
• EPA Substance Registry System: 1-O,2-O,3-O,4-O,6-O-Pentamethyl-β-D-mannopyranose(3445-71-4)

Safety Data

• Hazardous Substances Data: 3445-71-4(Hazardous Substances Data)

Upstream product

• 530-26-7 D-Mannose 
• 74-88-4 methyl iodide 
• 95690-55-4 Acetic acid (2R,3R,4R,5R,6S)-3,4,5-trimethoxy-6-{5-methoxy-4-oxo-2-[4-((2S,3R,4R,5R,6R)-3,4,5-trimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-4H-chromen-7-yloxy}-tetrahydro-pyran-2-ylmethyl ester 
• 95690-54-3 5-Methoxy-7-((2S,3R,4R,5R,6R)-3,4,5-trimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yloxy)-2-[4-((2S,3R,4R,5R,6R)-3,4,5-trimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-chromen-4-one 
• 67-56-1 methanol 
• 95690-50-9 7-Hydroxy-5-methoxy-2-[4-((2S,3R,4R,5R,6R)-3,4,5-trimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-chromen-4-one 
• 197631-81-5 phenyl 2,3,4,6-tetra-O-methyl-1-deoxy-1-thio-α-D-mannopyranoside S-oxide 

Downstream Products

• 3149-62-0 methyl 2,3,4,6-tetra-O-methyl-α-D-mannopyranoside 
• 492-93-3 1,5-anhydro-D-mannitol 

Relevant articles and documents

TOLL-LIKE RECEPTOR 9 AGONISTS

The present invention provides TLR9 agonists comprising, as an active ingredient, a compound represented by formula (I): (wherein a represents 0 or 1; n represents an integer of 0 to 2; m represents an integer of 0 to 5; X1 and X2 each independently represent a hydrogen atom or hydroxy; Y represents an oxygen atom or a sulfur atom; -Q1-represents -O- or the like; -Q2- represents -O- or the like; -Z- represents -O- or the like; R1, R3 and R4 each independently represent hydroxy or the like; R2 and R5 each independently represent a hydrogen atom, hydroxy or the like; and A represents 6-aminopurin-9-yl or the like) or a pharmaceutically acceptable salt thereof, and the like.

Peralkylation of Saccharides under Aqueous Conditions

Treatment of saccharides with sodium hydroxide and alkyl halides in aqueous dimethyl sulfoxide solution offers a very efficient method for the complete alkylation of saccharides in high yields.